Tag: blockers

The Rise of the Sartans?

~ Simon ~ 2 Comments

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Drug repurposing represents a more rapid way of bringing new treatments to the public than the traditional novel drug development route. It involves clinically testing therapies in new conditions for which they are not currently approved.

Researchers conduct large drug screening studies to identify agents that could be repurposed and basic science experiments can also provide data to support evaluating a particular class of drug in new medical conditions.

Recently, accumulating evidence has pointed towards a class of drugs called sartans as potential candidates for repurposing for Parkinson’s. 

In today’s post, we will discuss what sartans are and review some of new studies suggesting the case for support.

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The sartan family photo. Source: MDPI

The “Sartans” sound like an ancient Greek tribe or Scottish clan.

Like a formidable horde of Viking brigands bearing down on some hapless village that is unaware it is about to be pillaged. One can imagine someone in said village suddenly seeing something out of the ordinary, realizes the impending disaster, and screaming “the sartans are coming! The sartans are coming!”

Source: Lifeinnorway

But the reality is something else entirely.

Sartans are in fact a class of drugs that are widely used for the treatment of hypertension (that is: high blood pressure). They are also administered to patients with certain heart or kidney diseases. The drugs work by blocking the function of a hormone.

That hormone is called angiotensin II.

Angiotensin II has a bad habit of causing your blood vessels (the tubes that transport blood around your body) to narrow. This action can increase your blood pressure and force your heart to work harder. Not a good situation in terms of longevity.

And before we go any further it has to be said, like any marauding tribe, the sartans need to be treated with respect – they are powerful drugs and can do worse than simply making people feel dizzy if they lower the blood pressure too much.

Good to know. But what do sartans have to do with Parkinson’s?

Continue reading “The Rise of the Sartans?” →

When disco-needs-ya, can gene therapy help ya?

~ Simon ~ 4 Comments

 

With the recent announcement that the STEADY-PD III/Isradipine clinical trial did not reach its primary end point (that of slowing the progression of Parkinson’s), the winds of change have shifted with calls for a focus on biomarkers and better treatments, rather than disease modification.

Recently, researchers at Michigan State University have reported a novel experimental gene thearpy method for dealing with one of the most debilitating aspects of Parkinson’s – dyskinesias.

Ironically, their approach involves the same calcium channels that Isradipine blocks.

In today’s post, we will look at what dyskinesias are, what gene therapy is, and how this new approach could be useful for people currently burdened by these involutary movements.

 

Dyskinesia. Source: JAMA Neurology

There is a normal course of events following a diagnosis of Parkinson’s.

Yes, I am grossly over-generalising.

And no, I’m not talking from personal experience (this is based on listening to a lot of people), but just go with me on this for the sake of discussion.

First comes the shock of the actual diagnosis. For many it is devastating news – an event that changes the course of their lives. For others, however, the words ‘you have Parkinson’s‘ can provide a strange sense of relief that their current situation has a name and gives them something to focus on.

This initial phase is usually followed by the roller coaster of various emotions (including disbelief, sadness, anger, denial). It depends on each individual.

The emotional rollercoaster. Source: Asklatisha

And then comes the period during which many will try to familiarise themselves with their new situation. They will read books, search online for information, join Facebook groups (Click here for a good one), etc.

That search for information often leads to awareness of some of the realities of the condition.

And one potential reality that causes concern for many people (especially for people with young/early onset Parkinson’s) is dyskinesias.

What are dyskinesias?

Continue reading “When disco-needs-ya, can gene therapy help ya?” →