Site map

June 2017
The autoimmunity of Parkinson’s disease? – alpha synuclein, T cells, autoimmune, MHC complex, autoantibodies, antigen, candesartan, Treg cells
On the hunt: Parkure – Flies, drosophila, cure, repurposed drugs, Scotland, Edinburgh, drug screening, NRF2, Astemizole, antihistamine, Ketoconazole
Cholesterol, statins, and Parkinson’s disease – lipoproteins, lipids, Hydrophilic, lipophilic, PD STAT, clinical trial, simvastatin,
Who am I but my BMI – weight, risk of Parkinson’s, body mass index,
BioRxiv – open access preprints – manuscripts, arxiv, lrrk2, alpha synuclein, publishing
Are Dyskinesias days NAM-bered? – Dipraglurant, mGluR5, negative allosteric modulator, Addex Therapeutics, Michael J Fox Foundation, dyskinesias
The Melanoma drug from MODAG – melanoma, skin cancer, alpha synuclein, Anle138b
Flu jabs and Parkinson’s disease – influenza, virus, vaccination, vaccine
New stem cell transplantation trial for Parkinson’s proposed in China – embryonic stem cells, clinical trial, China, neuronal-precursors
Oleuropein – “surely the richest gift of heaven?” – antioxidant, olive tree, phenylethanoid, hydroxytyrosol, mTOR, autophagy, Alzheimer’s disease

May 2017
James: That essay – James Parkinson, history, essay on the shaking palsy, Paralysis agitans, 200 years, anniversary
Sheffield: flies, fish and a Tigar – UCDA, Ursodeoxycholic Acid, Ursodiol, zebrafish, mitochondria, Pink1, Lrrk2, Tigar, autophagy, mitophagy, Parkinson’s UK
A connection between ALS & Parkinson’s disease? Oh’ll, SOD it! – Amyotrophic lateral sclerosis, Lou Gehrig’s disease, motor neuron disease, free radicals, antioxidants, neuroprotective, Australia, SOD1, Cu-Zn superoxide dismutase, Cu(II)ATSM
Sar-gram-o-stim: The immunostimulation of Parkinson’s disease – immunomodulation, Sargramostim, Nebraska, clinical trial, Treg cells
Shining a light on movement – optogenetics, globus pallidus, movement, motor cortex, Channelrhodopsin, RetroSense
PARK2 and the big C – cancer, mutations, genetics, variants, Parkin, cell division
Rotten eggs, Rotorua and Parkinson’s disease – hydrogen sulfide, New Zealand, neuroprotection, H2S, antioxidants,
New drug approved for ALS – Edaravone, Amyotrophic lateral sclerosis, Lou Gehrig’s disease, motor neuron disease, free radicals, antioxidants, neuroprotective
The Antibiotic and Parkinson’s: Oppsy, they got doxy! – doxycycline, antibiotics, neuroprotection, 6-OHDA, Alexander Fleming,
Trying to digest gut research – microbiome, vagotomy, gut, gastrointestinal system, microbiota

April 2017
Improving Patient Education – Introducing Eirwen Malin – Patient education, Winston Churchill Memorial Trust, fellowship, Eirwen Malin, USA, Argentina,
Wearable Tech 4 Parkinson’s – self tracking, smart phone apps,
Stress and Parkinson’s disease – cortisol, stress, hydrocortisone, adrenal gland,
Old dogs, new tricks – repurposing drugs for Parkinson’s – Dibenzoylmethane, Trazodone, Alzheimer’s, neurodegeneration, prion, repurposing drugs, eIF2alpha, PERK
Iron, life force, and Parkinson’s disease – Iron overload, Chelator therapy, Prana Biotechnology, PBT434, ADPD2017
On astrocytes and neurons – reprogramming for Parkinson’s – Yamanaka, IPS cells, induced pluripotent stem cells, Sweden,
An Ambroxol update – active in the brain – Ambroxol, GBA, glucocerebrosidase, lysosomes, clinical trial, update, genetic mutation
Stimulating research in London (Canada) – spinal cord stimulation, Miguel Nicolelis, Duke, Mandar Jog, Western University, clinical study
Editorial: Putting 200 years into context – 200 year anniversary, James Parkinson, research, science, context, alpha synuclein, GBA
Milestones in Parkinson’s disease research and discovery – 200 year anniversary, James Parkinson, research, science, clinical trials, discovery, Frank Church.
The Enlightened Mr Parkinson – author, interview, Cherry Lewis, James Parkinson, 200 year anniversary,
Hepatitis – Parkinson’s goes viral? – virus, hepatitis B, hepatitis C, Friedrich Heinrich Lewy, Lewy bodies, Negri bodies, rabies, post-encephalitic Parkinsonism, Taiwan, alpha synuclein,
James: The man behind the disease (Part 1) – 200 year anniversary, James Parkinson,

March 2017
ADHD and Parkinson’s disease – Attention deficit hyperactivity disorder, dopamine, ritalin, methylphenidate, echogenicity, Park2, Parkin
Resveratrol: From the folks who brought you Nilotinib – red wine, antioxidants, sirtuins, grapes, Alzheimer’s, clinical trial, Parkin, Park2
A new theory of Parkinson’s disease – Ole Isacson, threshold, ascending, Simone Engelender, Braak, alpha synuclein, Lewy bodies, theory
A yeast model of Parkinson’s disease – Susan Lindquist, microorganism, yeast, genetics, RAB1, Nedd4, Yumanity
The Journal of Parkinson’s disease – special issue – 200 year anniversary, discoveries, special issue, OPEN ACCESS, L-dopa, history DBS, cell transplantation
The red headed mice of Boston – red hair, ginger, melanoma, MC1R, Nurr1, melanocortin-1 receptor

February 2017
Phase II trial launched for Nilotinib – cancer drug, Nilotinib, Georgetown University, clinical trial, phase II, Tasigna,
New kiwi research in Parkinson’s disease – Pericytes, tunneling nanotubes, alpha synuclein, lewy bodies, disease spread, New Zealand,
How pigs are helping with Parkinson’s disease – NTCELL, Living cell technologies, LCT, encapsulated cells, implantation, cerebrospinal fluid, choroid plexus, clinical trial,
Confirmation about that gut feeling? – microbiome, microbiota, gut, gastrointestinal tract, microorganisms, bacteria, sequencing
Pink flies in Leicester at it again – mitochondria, PINK1, PARKIN, flies, Leicester, ATF4
HIV and Parkinson’s disease – AIDS, HIV, virus, AIDS dementia complex, lentivirus, HAART
Busy day for Parkinson’s – 9/2/2017 – Blood test, diagnosis, neurofilament light chain, Nfl, Acorda therapeutics, inhalable L-dopa, clinical trial, phase 3
George H and Vascular Parkinsonism – mini stroke, George HW Bush, syndrome, Vascular, Arteriosclerotic, Parkinsonism, diabetes, high blood pressure,  Macdonald Critchley,
On bans and boycotts – editorial, travel ban, Executive Order 13769, conferences, SfN,
PARIS is always a good idea – PARIS1, Pink1, Parkin, mitochondria,
Something ‘new and fresh’ from Korea – Kainos, Korea, Clinical trial, FAF1, KM-819, apoptosis, inhibitor

January 2017
Parkinson’s 101 (care of Parkinson’s UK) – what is Parkinson’s, clinical trial, drug design, videos, Michael J Fox, Parkinson’s UK
A smartphone application for Parkinson’s disease – umotif, monitoring, technology, clinical study,
An Update from Voyager Therapeutics trials for Parkinson’s – AADC, gene therapy, clinical trial, update,
The Dogfish solution for Parkinson’s – dogfish, Spurdogs, Mud shark, Squalide, Squalamine, alpha synuclein, MSI-1436
Niacin rich diets for Pink flies – Pink1, early onset Parkinson’s, Niacin, NAD+, mitochondria, nicotinamide, PARP,
An interesting commentary on the interpretation of the Nilotinib trial results – Nilotinib, clinical trial, MAO-B inhibitors, DOPAC, HVA
NRF2 and Parkinson’s disease – antioxidants, transcription factor, Antioxidant response elements, alpha synuclein, Lrrk2, Ayurveda, Curcumin, turmeric
Improving the SoPD blog – any thoughts? – house keeping post, requesting feedback

December 2016
The road ahead – Parkinson’s disease research in 2017 – clinical trials, key research areas, slowing the disease, basic biology, replacing lost cells, early detection
Update – Mannitol and Parkinson’s disease – Manna, sweetener, CliniCrowd, Israel, social impact,
Mmmm, Chocolate – xocolātl, cacao, β-phenylethylamine, Kuna indians, Panama, white chocolate, dark chocolate
Blood transfusions and Parkinson’s disease – Blood, transfusion, prion, Alzheimer’s
A drug from Kalamazoo – Diabetes, Metabolic Solutions Development, MSDC-0160, Exenatide,
The biology of immortality and Parkinson’s disease – Shinya Yamanaka, IPS cells, regeneration, life extension
A brave new world: 21st Century Cures Act – Obama, FDA, new law, regulator, CDC
Gene therapy in Parkinson’s disease – virus, VY-AADC01, Voyager therapeutics, Aromatic L-amino acid decarboxylase, AADC, clinical trial,
Milk (Yes, milk) and Parkinson’s disease – milk, heptachlor epoxide, Honolulu Heart Study,
Gut reaction to Parkinson’s disease – microbiome, microglia, antibiotics, clinical study, Minocycline

November 2016
A new LAG in Parkinson’s – alpha synuclein, TM9SF2,  Lag3, lymphocyte-activation gene 3, disease progression
Get more EGCG. Drink green tea – green tea, alpha synuclein, EGCG, Epigallocatechin Gallate, monomers, oligomers, fibrils, Lewy bodies
Update – ISCC Stem cell Transplantation trial – SFN, cell transplantation, clinical trial, Melbourne, Australia, International Stem Cell Corporation, ISCO, hpNSC
Something different – Government funding for Parkinson’s research – Trump, US elections, BREXIT, research funding, EU, science funding
Prothena reports Phase 1b results for Parkinson’s immunotherapy – Affiris, clinical trial, passive immunity, Prothena, PRX002, vaccine, antibodies
The benefits (???) of Antioxidants – clinical trial, Coenzyme Q, free radicals, orac, oxidation, vitamins

October 2016
Interesting reading – Nature, prion, lewy bodies, transplantation
Inhaling L-dopa – inhaler, Arvid Carlsson, Oleh Hornykiewicz, Levodopa, George Cotzias, Acorda Therapeutics,
PAMs for Parkinson’s – Prexton, PXT002331, globus pallidus, mGluR4 positive allosteric modulator, dyskinesias, clinical study
The curious case of Bulgarian Gypsies and the incidence of Parkinson’s disease – incidence, statistics, Amish, population, disease burden, Japan

September 2016
Cannabis and Parkinson’s disease – marijuana, medicinal use, clinical studies
The mystery deepens – Melanoma and Parkinson’s disease – skin cancer, genetics
First film footage of Parkinson’s disease – Arthur Van Gehuchten, cinematography, Youtube, Lancet
Update: Stem cells trial for Parkinson’s disease – cell transplantation, clinical trial, Melbourne, Australia, International Stem Cell Corporation, ISCO, hpNSC
Vaccine for Parkinson’s – AFFiRiS update – clinical trial, vaccination, alpha synuclein, antibodies, Austria
On year in – anniversary, happy birthday, 12 months
Game changer for Alzheimer’s – antibodies, clinical trial, Aducanumab, beta-amyloid, alpha synuclein, Biogen

August 2016
Is there something in my eye? – eyeball, retina, veins, arteries, diabetes, Rosiglitazone
Nilotinib update – new trial delayed – Nilotinib, cancer drug, delayed clinical trial
Coffee and Parkinson’s disease it’s not just caffeine – coffee, caffeine, Quercetin, flavonoid

July 2016
Identical twins and Parkinson’s disease – Jeff and Jack Gernsheimer, GBA, Lrrk2, monozygotic, dizygotic, iPS cells, epigenetics
Pesticides and Parkinson’s disease – Farming, insecticides, rotenone, ground water, fungicides
Juvenile-onset Parkinson’s disease – PARK genes, Henri Huchard, Parkin, DJ1, Pink1, PODXL
Editorial note – Cambridge University, Stem cells, institute, Wellcome Trust, #MyView, awareness campaign
Traumatic brain injury and Parkinson’s disease – an association – traumatic brain injury, loss of consciousness, Alzheimer’s disease, Dementia pugilistica
Bees! Bees! Hark to your bees! – clinical trial, bee venom, Apitoxin, Apamin, Calcium channels
Nilotinib and Parkinson’s disease: an update – cancer drug, clinical trial, Tasigna, Novartis, leukemia, CML, autophagy, lysosome, c-Abl inhibitors
The GDNF Trial (Bristol) initial results – Glial cell-derived neurotrophic factor, GDNF, neurotrophic, MedGenesis, Bristol, Clinical trial, Parkinson’s UK, Cure PD Trust,
A gut feeling about gut feelings – vagotomy, Movement Disorder meeting, Berlin, Swedish, Danish, Norwegian

June 2016
New criteria for Parkinson’s disease – diagnosis, criteria, movement disorder
Your appendix and Parkinson’s disease – Appendectomy, alpha synuclein, gut, intestines, bacteria
Muhammad Ali (1942-2016) – famous, boxer, sports

May 2016
A change of dogma for Alzheimer’s disease? – beta amyloid, alpha synuclein, plaques, tangles, protein, aggregation, bacteria, microbes
The Autistic spectrum and Parkinson’s disease – Autism, aging, risk, incidence, PARK2, neuroleptics
Manna from heaven? Mannitol and Parkinson’s disease – alpha synuclein, sweetener, sugar, protein aggregation
The debate surrounding a new Stem cell transplantation trial for Parkinson’s – cell transplantation, clinical trial, Australia, International Stem Cell Corporation, ISCO, hpNSC
Finding PARK16 – PARK genes, genetics, ADORA1, familial
Blood test for Parkinson’s disease? – mitochondria, hyperactivity, clinical study, diagnosis

April 2016
An update on the connection between Melanoma and Parkinson’s disease – somatic mutations, PARK genes, Lrrk2, skin cancer
Helicobacter pylori and Parkinson’s disease – gut, intestines, microbes, bacteria, ALS-PDC, BMAA, Guam
Older siblings and Parkinson’s disease – brother, sister, Sweden, ALS, Schizophrenia
The Parkinson’s UK 2016 Gretschen Amphlet Memorial Lecture – Cambridge, Prof Barker, Parkinson’s UK, public lecture, cell transplantation, clinical trials
Something different – recognising a birthday – James Parkinson, anniversary, photo, portrait, Jean-Martin Charcot
Chromosome 22 and Parkinson’s disease – genetics, 22q11.2 deletion syndrome, DiGeorge syndrome, risk

March 2016
And now spit! – saliva, test, diagnosis, alpha synuclein
Another connection between skin and Parkinson’s disease – Rosacea, antibiotics, dermatitis
Does the age of onset make a difference? – statistics, demographics, early onset, juvenile Parkinsonism, Henri Huchard
Herpes Simplex virus and Alpha-Synuclein – immune system, antibodies, virus
Disco-needs-ya – the science of dyskinesias – involuntary movements, L-dopa, Chorea, Dystonia,

February 2016
A sense of (and the science of) smell – olfactory function, smell
Diagnosed 2500 years ago? No problem – India, Ayurveda, Kampa vata, Mucuna pruriens, L-dopa
Cleaning up with Ambroxol – Glucocerebrosidase, GBA, Ambroxol, clinical trial
Diabetes, Monster saliva, and Parkinson’s disease – glucose tolerance, diabetes, insulin, Gila monster, Exenatide, GLP-1 agonist, clinical trial
Something lrrk-ing in the water… – Lrrk2, Phosphorylation, urine, diagnostic test,
Brain (not Heart) warming research – warm brain, temperature
The science of focused ultrasound therapy – clinical trial, ultrasound, thalamotomy, pallidotomy
New Research – on how movement is controlled – basal ganglia, thalamus, direct/indirect pathways, optogenetics, dopamine
Improving diagnosis – autoantibodies, DATscan
New research – new targets of Lrrk2 – Lrrk2, Sergey Brin, dardarin, rab proteins

January 2016
New research – the disorder of Alpha Synuclein – monomeric, αlpha synuclein, protein aggregation
The vulnerability of dopamine cells in the brain – midbrain, dopamine, substantia nigra pars compacta, SNC, ventral tegmental area, VTA
New research – Urate and Parkinson’s – Ammonia, Inosine, antioxidant, blood
New Research -Shared genetic features – DNA methylation, common genetic markers, neurodegenerative disease
Viruses and Parkinson’s – a hit and run story? – influenza, H1N1, encephalitis lethargica, Spanish flu, H5N1, hepatitis C, chickenpox
The Placebo effect and Parkinson’s disease – dopamine, placebo, randomized double-blind study
Cell transplantation – Replacing what has been lost – Colorado, Columbia, Tampa Bay, clinical trials, Transeuro, Embryonic stem cells, lewy bodies

December 2015
GDNF and Parkinson’s disease – Synergen, glial cell-derived neurotrophic factor, neurturin, persephin, artemin, gene therapy, MedGenesis, NSgene, Amgen, Bristol, clinical trial
A call to arms – Parkinson’s, anniversary, 200 years
Parkinson’s disease and the cancer drug – Nilotinib, Tasigna, Novartis, leukemia, CML, autophagy, lysosome, clinical trial, c-Abl inhibitors
“Red hair, sir, in my opinion, is dangerous” – red hair, fair skin, frequency, incidence, MC1R

November 2015
The difference between men and women – frequency, incidence, Japanese, testosterone, Cox2
The Honolulu Heart Study – Japanese, smoking

October 2015
The smell of Parkinson’s disease – Joy Milne, Perth, Scotland, sebum, skin

September 2015
Do you have trouble lying? Parkinson’s and Personality traits – metabolism, prefrontal cortex
Vaccination for Parkinson’s disease – vaccine, alpha synuclein – AFFiRiS, clinical trial, vaccine, alpha synuclein, Prothena, Lewy body
Alzheimer’s news – prion, amyloid beta,
Melanoma and Parkinson’s – skin cancer
A gut feeling – intestines, stomach, vagus nerve, vagotomy