December 2022
Monthly Research Review – December 2022 – research overview, publications, clinical studies, new technology, reviews, videos
Getting serious about saunas – heat shock proteins, Alzheimer’s, shower, heat therapy, lower-limb warming
At last: Selnoflast – Roche, inflammasome, inflazome, inflammation, NLRP3,
Would the real James Parkinson please stand up – James Cumine Parkinson, likeness, British Dental Association, Bill Bryson
Can shaking hands fix shaking hands? – Coordinated reset stimulation, gloves, somatosensory system, vibrotactile coordinated reset, Synergic Medical Technology, stimulation
November 2022
Monthly Research Review – November 2022 – research overview, publications, clinical studies, new technology, reviews, videos
The trans-omics of -omics – coenzyme Q10, mitochondrial, PARKIN, PINK1, oxidation, superoxide, antioxidant, clinical trial
Disease modification-ish – eradication, correction, halting, reversing, progression, trajectory, ALS, Vitamin B12, Methylcobalamin, Eisai, homocysteine
October 2022
Monthly Research Review – October 2022 – research overview, publications, clinical studies, new technology, reviews, videos
The radiologist at a Parkinson’s conference – computed tomography (CT) scans, Alzheimer’s, low-dose ionizing radiation, case studies
A nod to immunomod with fingolimod – Gilenya, Novartis, dyskinesias, multiple sclerosis, FTY720, S1P receptor modulator, myriocin, Sphingosine-1-phosphate, lymphocytes
September 2022
Monthly Research Review – September 2022 – research overview, publications, clinical studies, new technology, reviews, videos
The mystery of melanoma – Melanocytes, melanin, alpha synuclein, autophagy, Anle138b, MODAG, dihydroxyphenylalanine, DOPA, CHRM1,
PWP: Parrots with Parkinson’s? – yellow-crowned parrot, Amazona ochrocephala, Lewy body, cellular inclusion, alpha synuclein, calcium-dependent secretion activator 2, CADPS2
August 2022
Monthly Research Review – August 2022 – research overview, publications, clinical studies, new technology, reviews, videos
Parkinsonism type 1 through infinity – Nosology, Prof Bill Weiner, “n-of-1”, redefining Parkinson’s, Pine tree
The Rise of the Sartans? – Angiotensin II, renin-angiotensin–aldosterone system, angiotensin-converting enzyme, ACE, antibodies, AGTR1 gene, angiotensin receptor blockers
July 2022
Monthly Research Review – July 2022 – research overview, publications, clinical studies, new technology, reviews, videos
Spice up your life – curcumin, curcuminoids, turmeric, clinical trials, Alzheimer’s, mild cognitive impairment, NRF2, alpha synuclein, Theracurmin, Meriva, bioavailability
Hydroxychloroquine… I kid you not – Quinine, chloroquine, COVID, anti-malarial, anti-inflammatory, autophagy, Toll-like receptors, Sjögren’s, rheumatoid arthritis
The heights of Parkinson’s – Lewy body diseases, substantia nigra, dopamine neurons, taller, vulnerable, postmortem analysis
Finding religion – apatheism, longitudinal studies, religiosity, Parkinson’s risk, spiritual beliefs, spirituality, faith, Brain Derived Neurotrophic Factor, BDNF
June 2022
Monthly Research Review – June 2022 – research overview, publications, clinical studies, new technology, reviews, videos
Does Yerbe Mate matter? – Paraguay, Argentina, Uruguay, Chimarrão, Ilex paraguariensis, bombilla, bomba, case–control study, coffee drinking
The modification of acidification – TMEM175, lysosomes, lysosomal storage disorder, Transmembrane Protein 175, Potassium channels, Caraway Therapeutics, AbbVie, Merck
Planning ahead – a warning regarding not planning for the unknown future
Finding a talisman – Bhutan, N-of-one, N-of-1, low oxygen, Hyperbaric oxygen therapy, trial, altitude, Michael J Fox, Fred Ransdell, Bas Bloem
May 2022
Monthly Research Review – May 2022 – research overview, publications, clinical studies, new technology, reviews, videos
Oh, you sweet thing – Sugar consumption, carbohydrate intake, pain, cognitive decline, depression, impulse control disorder, glycation, Advanced Glycation End product, AGEs
Oh dear: Dairy? – Cheese, milk, ice cream, Mendelian randomisation, lactase persistence, heptachlor epoxide,
April 2022
Monthly research review-April 2022 – research overview, publications, clinical studies, new technology, reviews, videos
Breathtaking research – BIRAX, Breath, British Council, Cambridge, Israel, volatile organic compounds, VOCs, Technion, Hossam Haick, Roger Barker, Joy Milne
A rising tide with liraglutide – exendin-4, glucagon like peptide-1, GLP-1, exenatide, diabetes, insulin, Bydureon, clinical trial, Phase 2, results, Cedar Sinai
Be one with Vitamin B1 – Thiamine, Beriberi, essential micronutrients, Takaki Kanehiro, Antonio Costantini, high dose thiamine, Benfotiamine
The Llama-nation of LRRK2 – Leucine-rich repeat kinase 2, antibodies, immunoglobulin light chain, Camelidae, Nanobodies, blood brain barrier, Ablynx, Novo Nordisk, Wally, Winter
March 2022
Monthly research review – March 2022 – research overview, publications, clinical studies, new technology, reviews, videos
Silver linings – the results of an exploratory online survey asking if there are any silver linings to Parkinson’s
Parkinson’s research in Nigeria – Resveratrol, trans-astaxanthin, kolaviron, Nigerian Parkinson’s Disease Registry, hypoestoxide, PECKO-D study, clinical trial, mPower2.0
From NADPARK to NOPARK – nicotinamide riboside, nicotinic acid, niacin, vitamin B3, nicotinamide, Nicotinamide adenine dinucleotide, NAD, clinical trials, Adenosine Triphosphate, ATP, mitochondria
February 2022
Monthly Research Review – February 2022 – research overview, publications, clinical studies, new technology, reviews, videos
GCase: Mutants matter? – GBA1, GBA, idiopathic Parkinson’s, Gauchers, ambroxol, glucocerebrosidase, lysosome, lysosomal dysfunction,
Patients not patents – A rant about intellectual property, Agora Open Science Trust, M4K Pharma, M4ND, Parkin, ASAP, CLIC1, Cliacept
Are we Enterin a new age? – ENT-01, Squalamine, Trodusquemine, alpha synuclein, aggregation, dogfish shark, clinical trial, MSI-1436, ENT-01, RASMET, KARMET, constipation
The mannitol clinical trial results – Clinicrowd, manna sugar, crowd sourced platform, olfaction, smell, osmolytes, molecular chaperones, HSP-70
January 2022
Monthly Research Review: January 2022 – research overview, publications, clinical studies, new technology, reviews, videos
The luminance of a lighthouse – Denali therapeutics, Leucine-rich repeat kinase 2, LRRK2 inhibitor, G2019S, kinase, clinical trials, pharmacodynamics, pharmacokinetics, RAB10, DNL151, Biogen
The “What would I do” post? Part 2 – a follow-up post describing what I would do if I was diagnosed with Parkinson’s today.
The road ahead: 2022 – expectations, clinical trials, 2020, therapeutics, drugs, treatments, “cure”, disease modifying therapies, cell transplantation, gene therapy
December 2021
Year in review: 2021 – annual review of Parkinson’s research
Monthly Research Review – December 2021 – research overview, publications, clinical studies, new technology, reviews, videos
The terazosin pilot study results – Iowa, enlarged prostate, benign prostatic hyperplasia, hypertension, α1-adrenergic receptor antagonist, Phosphoglycerate kinase 1, Adenosine Triphosphate, ATP, glycolysis, 31P-MRS, pilot clinical trial
Slow-wave sleep saves synucleinopathy? – Alpha synuclein, aggregation, Alzheimer’s, beta amyloid, Jazz Pharmaceuticals, narcolepsy, Orphan Medical, REM, deprivation, sodium oxybate, Tau, UCB, VMAT2, XW10172, XWPharma, Xyrem
From wearables to invisibles – WI-FI, phenotyping, monitoring Parkinson’s progression, Dina Katabi, Emerald Innovations, radio frequency
ADepTing to the UCB-Novartis deal – Alpha synuclein, aggregation, anle138b, ADepT-PD, MODAG, TEVA, small molecule, immunotherapy, Nortriptyline, NPT200-11, UCB0599, UCB7853, tricyclic anti-depressants
Getting a handle on Miro1 – Mitochondria, mitophagy, PINK1, Parkin, Leucine-rich repeat kinase 2, LRRK2, AcureX Therapeutics, Miro1 reducer, biomarkers
November 2021
Monthly research review – November 2021 – research overview, publications, clinical studies, new technology, reviews, videos
The influence of influenza – GCase, GBA, Glucocerebrosidase, H1N1, H5N1, pandemic, Spanish flu, 1918, odds ratio, viral, virus, epidemiological research, case-controlled study
Turn back Bach? – antioxidants, oxidative stress, Nuclear Factor Erythroid 2-Related Factor 2, NRF2, antioxidant response elements, ARE, reactive oxygen species, superoxide, free radicals, adenosine triphosphate, ATP, vTv Therapeutics, repressor
ASAP 2021 funding – Aligning Science Across Parkinson’s, research grant funding for Parkinson’s
Administrative: No more Meta – No more SoPD Facebook page
October 2021
Monthly Research Review – October 2021 – research overview, publications, clinical studies, new technology, reviews, videos
Mo better for TEVA with Modag? – alpha synuclein, protein aggregation, MSA, Anle138b, SERY433, biotech, clinical trials
ELOVL me tender – astrocytes, Ben Barres, CHOP, cytokines, elovl1, lipids, lipoapoptosis, lipoprotein, long chain satuated fatty acids, PUMA, Alzheimer’s
Repurposing bumetanide for Alzheimer’s – Apolipoprotein E4, APOE4, Loop diuretic, NKCC1 chloride importer, B&A Therapeutics, physical activity
Mind blowing modulation of mind – Deep brain stimulation, optogenetics, basal ganglia, direct pathway, indirect pathway, globus pallidus, Lim homeobox 6, Parvalbumin
Omega+omega=a mega result? – essential fatty acids, omega 3, omega 6, Neuroaspis PLP10, polyunsaturated, monunsaturated, clinical trial, PALUPA Medical, Multiple sclerosis
Making a (G)case for quetiapine – GBA1, GBA, idiopathic Parkinson’s, Gauchers, ambroxol, antipsychotic, glucocerebrosidase, GCase, lysosome, lysosomal dysfunction, drug repurposing
September 2021
Monthly Research Review – September 2021 – research overview, publications, clinical studies, new technology, reviews, videos
When sonic hedgehog goes dyskinetic – Smoothened, Patched, cholinergic neurons, Robotnikinin, dyskinesia, involuntary movement
Because I’m all about that base – Base excision repair, DNA repair, PARP, nicotinamide riboside, oxidative stress, mitochondria, Endonuclease III-like protein 1, NTH-1, mitohormesis
August 2021
Monthly Research Review – August 2021 – research overview, publications, clinical studies, new technology, reviews, videos
When we talk about “disease modification” – clinical trials, symptomatic effects, placebo, Anavex Life Sciences,
RePOOPulating the gut – fecal transplantation, microbiota, 4D Pharma, MRx0029, MRx0005, Chain biotech, microbiota
Getting expansive about treg cells – ALS, Alzheimer’s, autoimmunity, AZTherapies, CART T-cells, cytotoxic T-cells, Carisma Therapeutics, T cells, T-helper, t-effector
July 2021
Monthly Research Review – July 2021 – research overview, publications, clinical studies, new technology, reviews, videos
AC Immune acquires assets of AFFiRiS – immunotherapy, antibodies, vaccines,
Farnesol: The farnesylator of PARIS – PGC-1α, farnesylation, ZNF746, Parkin Interacting Substrate, Zinc Finger Protein 746, peroxisome proliferator-activated receptor γ coactivator-1α
The Bluerockers have started – cell transplantation, IPS cells, dopamine neurons,
Let’s talk snus use – Sweden, smokeless, tobacco, nicotine, epidemiological analysis
June 2021
Monthly Research Review – June 2021 – research overview, publications, clinical studies, new technology, reviews, videos
The Anavex results – Sigma-1 receptor agonist, ANAVEX2-73, blarcamesine, Anavex Life Sciences, clinical trial, Phase 2, Parkinson’s Disease Dementia, PDD, Prilenia Therapeutics, Pridopidine
EJS-ACT PD – Multi-Arm Multi-Stage, MAMS, clinical trials, disease modification, Phase 1, Phase 2, Phase 3, adaptive, stampede, prostate, Edmund J. Safra Foundation
Monitoring an Apple in motion – Smart watch, wearable technology, dyskinesia, tremor, Verily, Alphabet, Google, FDA, Motor fluctuations Monitor for Parkinson’s Disease, MM4PD
G.P.N.M.B – Gaucher disease, GBA-associated Parkinson’s, glycoprotein non-metastatic melanoma protein B, GPNMB, biomarkers, glucocerebroside, glucocerebrosidase, GCase
Does immunotherapy need therapy? – Alzheimer’s, monoclonal antibodies, microglia, NLRP3 inflammasome, lymphatic dysfunction, inflammation, VEGF-C, LYT-300
Arukiddingmab? – A piece of creative writing about an idiotic situation
May 2021
Monthly Research Review – May 2021 – research overview, publications, clinical studies, new technology, reviews, videos
Denali’s Phase I results – Leucine-rich repeat kinase 2, LRRK2 inhibitor, G2019S, kinase, clinical trials, pharmacodynamics, pharmacokinetics, RAB10, DNL151, Biogen
Unmasking LRRK2 and GBA – Leucine-rich repeat kinase 2, glucocerebroside, glucocerebrosidase, GCase, genetic risk factors, Peacock feathers
April 2021
Monthly research review – April 2021 – research overview, publications, clinical studies, new technology, reviews, videos
UCB at ANN looks A-OK – UCB0599, Neuropore Therapies, NPT200-11, NPT100-18A, NPT520-34, alpha synuclein, aggregation, MODAG, anle138b, Annoivs, ANVS-401, Posiphen, ORCHESTRA study, Phase I, clinical trial
ISRIB: The ISR InhiBitor – ABBV-CLS-7262, ATF4, DNL343, EIF2Α, GCN2, HRI, Integrated stress response, ISR, inhibitor, ISRIB, Kinase, PERK, PKR
500 – the 500th post of the SoPD website
March 2021
Monthly research review – March 2021 – research overview, publications, clinical studies, new technology, reviews, videos
Synucleinopathy begets channelopathy? – A53T, alpha synuclein, constipation, Dalfampridine, DMNV, Dorsal motor nucleus of the vagus nerve, Fampridine, KV4, SCA6, Spinocerebellar ataxia Type 6
What is GDNF without RET? – Glial cell line-derived neurotrophic factor, Nurr1, Ret proto-oncogene, alpha synuclein, phosphorylated ribosomal protein S6, GDF5, BMP5/7
Bringing Joy to Parkinson’s research – Carnitine shuttle, Joy Milne, sebum, smell, Tilo Kunath, Perdita Barran, Volatile Organic Compounds, VOCs, sphingolipid
Isradipine: Posthoc analysis – STEADY-PD, clinical trial, Phase III, Dynacirc, calcium channel blocker, L-type, alpha synuclein, pharmacokinetics
What TDO about KMO? – kynurenine pathway, 3-hydroxykynurenine, 3-HK, quinolinic acid, QUIN, kynurenic acid, KYNA, tryptophan dioxygenase, Netherlands Translational Research Center, kynurenine 3-monooxygenase
February 2021
Monthly Research Review – February 2021 – research overview, publications, clinical studies, new technology, reviews, videos
Forget Special K, maybe focus on LysoK – lysosome, growth factors, TMEM175 , Q65P, p.M393T, potassium channel, AKT, Caraway therapeutics, Merck, Lewy body dementia
Our approach to failure – clinical trials, postmortem analysis, Pasadena study, MOVE-PD, SPARK, Roche, Sanofi, Biogen, investigation, communication
The basket case -clinical trial design, Tau, phenotyping, Alzheimer’s, progressive supranuclear palsy, PSP, corticobasal syndrome, TPI-287, tauopathies, Cincinnati Cohort Biomarker Program, CCBP, All of Us,
Trying to LIMP-2 the lysosome – GBA, GBA1, GCase, fibroblasts, Glucocerebrosidase, lysosome, lysosomal function, genetic variants, ambroxol, glucocerebroside, Gaucher
Being ly-mphatic about drainage issues – Lymph, nodes, lymphatic, VEGF-C, Puretech health, alpha synuclein, Deupirfenidone, LYT-100, Meninges, Alzheimer’s, clearance
January 2021
Monthly Research Review – January 2021 – research overview, publications, clinical studies, new technology, reviews, videos
The age-associated changes of PARKIN – PARK2, oxidative changes, insoluble, antioxidant, Cellivery, iCP-PARKIN, neuromelanin, Vincere bioscience, Progenra
2021: Wish list – four themes I am hoping to see in 2020
The road ahead: 2021 – expectations, clinical trials, 2020, therapeutics, drugs, treatments, “cure”, disease modifying therapies, cell transplantation, gene therapy
December 2020
2020: Year in Review – annual review of Parkinson’s research
Monthly Research Review – December 2020 – research overview, publications, clinical studies, new technology, reviews, videos
PARP-kinson’s goes chlorogenic -chlorogenic acid, coffee, Poly (ADP-ribose) polymerase, PAR, DNA repair, alpha synuclein, poly-ADP ribose, RNF146, liquiritigenin, Glycyrrhizae uralensis, PARP-1
Prevail lands on a Lilly pad – Eli Lilly, GBA, GCase, lysosome, Gaucher, PR001 , Silverstein, gene therapy, AAV9, clinical trial, Phase I, glucocerebrosidase
TGF-beta: The Parkinson’s superfamily? – BMP5, BMP7, c-RET, GDNF, glial cell line-derived neurotrophic factor, GDF5, neurotrophic factors, smad1, smad6, Transfomring growth factor-B
Bayer doubles down on Parkinson’s? – gene therapy, AAV-GDNF, Askbio, Askleppios, BNB, Brain Neurotherapy Bio, glial cell line-derived neurotrophic factor, clinical trial
Curasen: Shifting the focus from just dopamine – Beta-Adrenoreceptor, CST-2032, Epinephrine, Locus Coeruleus, Noradrenergic, Norepinephrine, clinical trial
The drug development pipeline for Parkinson’s – clinical trials, advocacy, annual review, 2019, Phase, symptomatic, disease modifying,
November 2020
Monthly Research Review – November 2020 – research overview, publications, clinical studies, new technology, reviews, videos
EDITORIAL: Paywalls – scientific research publishing, cOAlition, Elsevier, impact factor, Nature, OPEN ACCESS, Plan S, Springer
Very Keynesian: Cell painting – cell culture, phenotype, genotype, google research, , database, bioRxiv, manuscript, fibroblast,
CMT-3: A better option than doxy? – antibiotic, tetracycline, doxycycline, chemically modified, antibacterial, COL-3, Incyclinide, Metastat, minocycline, alpha synuclein,
ALS: From ice bucket to centaur – AMX0035, amylxy, ALSFRS, sodium phenylbutyrate, TUDCA, Taurursodiol, Tauroursodeoxycholic acid, Lou Gehrig’s disease, motor neuron disease, amyotrophic lateral sclerosis, Phase II, clinical trial
Yo DJ, stop mis-splicing – DJ-1, DJ1, Antioxidant, cytokinin, DNA, exon, familial dysautonomia, free radical, intron,Kinetin, NRF2, oxidative stress, PARK7, phenylbutyric acid, RECTAS, snRNP, spliceosome,
Administrative post: Approaching 500 – A request to readers on how to mark a small milestone
Ending Par(aquat)-kinson’s – paraquat, herbicide, Jacinda Ardern, New Zealand, PD avengers, Ending Parkinson’s disease, book, non-selective, oxidant, indiscriminate, EPA, association
T-cells: First responders – CD4, CD8, Cytotoxic, helper, hematopoiesis, leukocytes, immune system, lymphocytes, incidental Lewy body disease, Lewy pathology
October 2020
Monthly research review – October 2020 – research overview, publications, clinical studies, new technology, reviews, videos
Is there something in the air? – Mexico City, Tau, alpha synuclein, beta amyloid, TDP-43, pollution, PM2·5 concentrations, PM10, Cyclooxygenase-2, COX2
When Inflazome becomes Roche – inflammasome, inflammation, NLRP3,
Further support for GLP-1R agonists – exendin-4, glucagon like peptide-1, GLP-1, exenatide, diabetes, insulin, Bydureon, Tirzepatide, glucose-dependent insulinotropic polypeptide, GIP, DPP-4, dipeptidyl peptidase 4, glitazones, thiazolidinediones
A PINK shade of inflammation – PARKIN, early onset Parkinson’s, EOPD, inflammasome, PINK1, mitophagy, Interleukin 6, IL-6, C-reactive protein, CRP, circulating cell-free mtDNA, cGAS-STING, interferon, acetylsalicylic acid, aspirin
The world according to GARP -LRRK2, Leucine-rich repeat kinase 2, VPS52, Golgi-associated retrograde protein, complex, endosomes, endoplasmic reticulum, transport, LRRK2 inhibitor
The 2020 Linked Clinical Trials meeting – LCT, Cure Parkinson’s trust, Van Ande Institute, drug repurposing, clinical trials, exenatide, ambroxol, Tom Isaacs, Richard Wyse, Patrik Brundin
September 2020
Monthly Research Review – September 2020 – research overview, publications, clinical studies, new technology, reviews, videos
Problems with PARKIN in PARIS – PINK1, mitophagy, mitochondria, biogenesis, PGC-1a, zinc finger protein 746, ZNF746, respiration, energy production, waste disposal
$161 million over three years – LRRK2, Aligning Science Across Parkinson’s, research funding, basic science
The PASADENA study announcement (part 2) – immunotherapy, clinical trial, Roche, Prothena, antibody, alpha synuclein, SPARK study, Biogen, prasinezumab
CPTX: Gluing the brain back together – Alzheimer’s, axon, Cbln1, Cerebellar ataxia, cerebellin-1, pentraxin 1, NP1, spinal cord injury, synapse, synaptic organizing proteins
A tête-à-tête about TET2 – epigenetics, DNA methylation, demethylation, inflammation, cell cycle, gene, Ten-Eleven Translocation, methyl group
August 2020
Monthy research review – August 2020 – research overview, publications, clinical studies, new technology, reviews, videos
Can sigma-1 get it done? – Shake It Up Australia Foundation, Anavex Life Sciences, ANAVEX2-73, blarcamesine, Clyde Campbell, Australian Parkinson’s Mission, endoplasmic reticulum, mitochondria-associated membrane, Pridopidine, Prilenia Therapeutics
The ibuprofen post – nonsteroidal anti-inflammatory drug, Leucine-rich repeat kinase 2, LRRK2, aspirin, inflammasome, inflammation, Inzomelid, Azathioprine, XPro1595, Inflazome, InmuneBio
Billion dollar bets: Denali+Biogen – Leucine-rich repeat kinase 2, LRRK2, inhibitor, DNL201, DNL151, blood-brain barrier, tranferrin, Transport Vehicle, TV technology platform,
July 2020
Monthy research review – July 2020 – research overview, publications, clinical studies, new technology, reviews, videos
Smarter than the average björn – IQ, intelligence, smoking, Sweden, Swedish Military Service Conscription Registry, associations, LRRK2, PINK1, PARKIN, genetic risk factors
Does Parkinson’s have us by the short and curli? – Gut bacteria, gastrointestinal system, microbiota, aggregate, amyloid, autoimmune, bacteria, EGCG
The Stanford Parkinson’s Disease Plasma Study – Alkahest, Alzheimer’s, clinical trial, GRF6019, GRF6021, Grifols infusion, plasma fractions, results, Stanford Parkinson’s Plasma Study
Ptbp1: “One and done”(?) – astrocytes, dopamine, glial cells, polypyrimidine tract-binding protein 1, Ptbp1, regenerative, reprogramming, antisense oligonucleotides, restorative
June 2020
Monthy research review – June 2020 – research overview, publications, clinical studies, new technology, reviews, videos
GBA: Wider regulation = wider implications –
The hunt for a vaccine –
Dexamethasone for Parkinsons? Not so elementary my dear Watson – artificial intelligence, IBM, immunosuppression, anti-inflammatory,
GTCA –
Oligodendrocytes?!? – GWAS, single cell sequencing, myelin, nodes of ranvier, Del Río Hortega,
Disney’s “Attack of the synucleozid from Jupiter” – alpha synuclein, iron responsive element, RNA, Ribosomes, antisense oligonucleotide,
May 2020
Monthly Research Review – May 2020 – research overview, publications, clinical studies, new technology, reviews, videos
Oleh Hornykiewicz (1926-2020) –
PDCORE – clinical trial, assessment, symptoms, progression, GDNF, Bristol trial, composite score, UPDRS, post hoc analysis, ADCOMS
Skin in the game –
MAMS the word – clinical trial design,
Getting a GRP on dyskinesias –
Putting the PARKIN back into Parkinson’s – Cellivery, CP-PARKIN, iCP-PARKIN, alpha synuclein, E3,
April 2020
Monthly Research Review – April 2020 – research overview, publications, clinical studies, new technology, reviews, videos
The Pasadena study announcement –
CasRx Reprogramming –
The Aspirations of Aspen –
The STEADY-PD trial results – therapy
March 2020
Monthly Research Review: March 2020 – research overview, publications, clinical studies, new technology, reviews, videos
Something new for neurturin – neurotrophic factor, GDNF, clinical trial, gene therapy, postmortem, brain analysis,
Direct dopamine delivery – levodopa, intracerebral, dyskinesia, ventricles, a-dopamine, oxidative stress, Duodopa, InBrain Pharma
The COVID-19 post –
A case for chondroitinase? –
Too much LRRK2 begets too little GCase? –
Going viral –
Revise or reconstruct? –
February 2020
Monthly research review: February 2020 – research overview, publications, clinical studies, new technology, reviews, videos
The Phase 1/2 CDNF topline results –
Differentiating PD from MSA – alpha synuclein,
The Minnesota UDCA study – Ursodeoxycholic acid, Sheffield, clinical trial, Phase 1, Ursodiol, bile acid, mitochondria
That time APOE met Alpha Syn –
The Wim Hof method –
A plutocratic proposal: iCancer –
January 2020
Monthly Research Review: Jaunary 2020 – research overview, publications, clinical studies, new technology, reviews, videos
Natural (born) killers –
Probiotics: Food for worms? – Caenorhabditis elegans, Bacillus subtilis, alpha synuclein, worms, microbiota, gut, bacteria, Alzheimer’s, Symprove, aggregates
Not dead, dormant dopamine neurons?!? – MAO-B, astrocytes, GABA,
The Ambroxol Results – clinical trial, lysosomal storage disorder, GBA,
2020 wish list – three themes I am hoping to see in 2020
The road ahead: 2020 – expectations, clinical trials, 2020, therapeutics, drugs, treatments, “cure”, disease modifying therapies, cell transplantation, gene therapy
December 2019
2019: Year in review – annual review of Parkinson’s research
Monthy research review – December 2019 – research overview, publications, clinical studies, new technology, reviews, videos
The Lords of LRRK – Dario
DBS: location, location, location – deep brain stimulation,
ROPAD + LIPAD = NOT BAD 🙂 – centogene,
The inflammasome field is heating up –
The Tau of LRRK2 –
November 2019
Monthly Research Review – November 2019 – research overview, publications, clinical studies, new technology, reviews, videos
Making a strong case for GCase –
AMP-PD is here –
Distinctly human: Kangaroos –
There’s gold in them tha brains – Clene Nanomedicine,
Shining a light on Parkinson’s –
The Neuraly trial – GLP1 agonists,
Improving the SoPD blog – any thoughts? – a request for help to improve/evolve the SoPD website
October 2019
Monthly research review – October 2019 – research overview, publications, clinical studies, new technology, reviews, videos
Say it with me: Farn-e-syl-trans-fer-ase –
An exercise in expectations: Exenatide III – Phase III clinical trial, managing expectations, GLP1 agonists, Phase II clinical trial results,
The 2019 Linked Clinical Trials meeting – LCT, Cure Parkinson’s trust, Van Ande Institute, drug repurposing, clinical trials, exenatide, ambroxol, Tom Isaacs, Richard Wyse, Patrik Brundin
Something LRRKing in the immune system –
When miro just can’t let go –
Is it time to back NAC? –
Administrative news: One year #PostAc – new job anniversary, still loving it, advice for career changing researchers,
September 2019
Monthly Research Review – September 2019 – research overview, publications, clinical studies, new technology, reviews, videos
A.S.A.P – Aligning Science Across Parkinson’s, Sergey Brin, Randy Schekman, Google, collaboration, open access, data sharing, basic science,
A new reason to hate mosquitos? – marlaria, virus, alphavirus, Western equine encephalitis virus, alpha synuclein, protein aggregation,
Repurposing: From enlarged prostates to Parkinson’s – terazosin,
The exergaming of Parkinson’s – clinical trial, result, exercise, aerobic, exergaming, exercycling, maximum heart rate, resting heart rate,
DNA repair: Alpha synuclein to the rescue – Nucleus, DNA repair respond, DNA damage, immunotherapy, poly-ADP-ribose, PAR, histone 2AX, H2AX,
Resolvin(g) Parkinson’s – Resolvin D1, inflammation, interferons, dopamine neurons, cell loss, neurodegeneration, immune response, resolution, cytokines,
Interfering with interferons – hepatitis C viral infection, virus, big data, Taiwan, interferon treatment, therapy
August 2019
Monthly Research Review – August 2019 – research overview, publications, clinical studies, new technology, reviews, videos
A re-think of PINK – gut, PARKIN, PARK2, infection, stomach bug, autoimmune disease, inflammation, anti-inflammatory
Viva Las Vagus – gut, ENT-01, Enterin, vagotomy, vagus nerve, Braak, dorsal motor nucleus of the vagus, DMNV, alpha synuclein, fibrils, aggregation
When Bluerock became Bayer – cell replacement therapy, cell transplantation, dopamine neurons, clinical trials, stem cells, Lorenz Studer,
Man’s best friend – Smell, odour, Medical Detection Dogs, Milton Keynes, Claire Guest, Joy Milne, canine, prodromal
July 2019
Monthly Research Review – July 2019 – research overview, publications, clinical studies, new technology, reviews, videos
“Transdiagnostic” clusters – Alzheimer’s, ALS, FTD, Frontal temporal dementia, disease clustering, Brian Walloch, algorithms,
Guten tag! MODAG – Anle138b, multiple systems atrophy, Lewy bodies, alpha synuclein, aggregation, inhibitor, clinical trial, biotech,
June 2019
Monthly Research Review – June 2019 – research overview, publications, clinical studies, new technology, reviews, videos
Dream, struggle, create, Prevail – gene therapy, GBA, Silverstein Foundation, glucocerebrosidase, Gauchers disease,
I’m worried about my IMM-AGE –
Making sense of antisense – oligonucleotides, Biogen, LRRK2, alpha synuclein, Huntington’s, ALS, Spinal muscular atrophy, Ionis, clinical trial,
“So, will my head glow in a disco?” – near-infrared, ultraviolet, UV, emission, imaging, amyloid protein, Alzheimer’s, aggregates, fibrils, lewy bodies, alpha synuclein, beta amyloid
WPC 2019 – Day 3 – World Parkinson’s congress meeting, conference, Kyoto, Japan, advocacy, patient involvement
WPC 2019 – Day 2 – World Parkinson’s congress meeting, conference, Kyoto, Japan, advocacy, patient involvement
WPC 2019 – Day 1 – World Parkinson’s congress meeting, conference, Kyoto, Japan, advocacy, patient involvement
WPC 2019 – Day 0 – World Parkinson’s congress meeting, conference, Kyoto, Japan, advocacy, patient involvement
May 2019
Monthly Research Review – May 2019 – research overview, publications, clinical studies, new technology, reviews, videos
Remembering Tom – Tom Isaacs, the Cure Parkinson’s Trust, Parkinson’s advocacy, involvement
Parkinson’s UK: Golden anniversary – 50th anniversary, Parkinson’s disease society, Parkinson’s foundation, National Parkinson Foundation, Jeanne C. Levey, William Black, Mali Jenkins
When disco-needs-ya, can gene therapy help ya? – calcium channels,
The 2019 World Parkinson’s Congress –
Monitoring Parkinson’s: Under pressure –
I’ve got gum disease on my mind – alpha synuclein, Alzheimer’s, antimicrobial, antiviral, bacteria, beta amyloid, Cerezyme, COR388, gingipain, gum, microbial, viral, virus
April 2019
Monthly Research Review – April 2019 – research overview, publications, clinical studies, new technology, reviews, videos
All we need to do is block CD22? – microglia, B-cell receptor, phagocytosis, CRISPR
A fine time for Felodipine? – autophagy, Huntington’s disease, alpha synuclein, aggregated protein, clinical trial, Isradipine, STEADY-PD, L-type Calcium channel blocker, A53T
The other GDNF clinical trial – clinical trial, glial cell line-derived neurotrophic factor, AAV virus, gene therapy, adeno-associated, neurotrophic factor, regenerative medicine
Sonic Hedgehog (I kid you not) – development, LRRK2, GDNF, flies, genetics, Purmorphamine, smoothened, patched, cancer, inhibitor, activator
Time to resTOR in New Zealand – mTOR, TORC1, TORC2, rapamycin, inhibitor, RBT101, clinical trial,
When undruggable becomes druggable – Nuclear receptor related 1 protein, NURR1, NR4A2, nuclear receptor subfamily 4 group A, 5,6-dihydroxyindole, DHI, alpha synuclein
The 2019 ADPD meeting –
March 2019
Monthly Research Review – March 2019 – research overview, publications, clinical studies, new technology, reviews, videos
IPDGC: The genetics of Parkinson’s – International Parkinson Disease Genomics Consortium, GWAS, DNA, PARK genes, genetic risk factors, Accelerating Medicines Partnership, AMP
Deep Mitochondrial stimulation? –
AdoCbl + LRRK2 = modulation – vitamin B12, adenosylcobalamin, Leucine-rich repeat kinase 2, Park 8, G2019S, inhibitors, Denali, Methylcobalamin, cobalamin
The Joy of discovery: On the smell of Parkinson’s – Joy Milne, sebum, Tilo Kunath, Volatile Organic Compounds, VOCs, Seborrhea, perillic aldehyde, eicosane
Neu-Ro-Mela-Nin – neuromelanin, Lewy bodies, alpha synuclein, tyrosinase, transcription factor EB, TFEB, Ambroxol
The Eve of Parkinson’s – women, females, LRRK2, Parkinson’s Eve, research, menopause, menstruation, pregnancy
We need to talk about the UPDRS – assessment, unified Parkinson’s disease rating scale, MDS, movement disorder society, wearables, objective, Andy Grove
Distinctly human? – models of Parkinson’s, killifish, Nothobranchius furzeri, alpha synuclein, Lewy bodies, neurodegeneration, primates
February 2019
Monthly Research Review – February 2019 – research overview, publications, clinical studies, new technology, reviews, videos
The Bristol GDNF results – clinical trial, glial cell line-derived neurotrophic factor, CDNF, Amgen, Medgenesis, Herantis, Genecode, CERE-120, Neurturin, gene therapy
One ring to rule them all – Ōura, MOTIV, sleep, phase, polysomnography, monitoring, assessment, self tracking, smart ring, REM
A focus on GBA-Parkinson’s – Silverstein foundation, Michael J Fox foundation, beta glucocerebrosidase, GCase, Rheostat Therapeutics, Gain Therapeutics, Gaucher disease
Clinical trials: Trying to make them SEAMless – phase I, II, III, regulators, process, crowd sourcing, hacking, solutions, SEAM, Barry Chandler, Meetup
Parkinson’s: When evolution leaves parts of us behind? – mitochondria, cortex, midbrain, genetics, calcium channels,
Bac to the future – bacteria, gut, microbiota, levodopa, DOPA decarboxylase, Tyrosine decarboxylase, antibiotics, Synlogics, SYNB1618, jejunum, small intestine
The UP Study – UDCA in Parkinson’s – Ursodeoxycholic acid, Sheffield, clinical trial, PARK2, Parkin, PARK8, LRRK2, Ursodiol, bile acid, mitochondria
On your MARCKS. Get set. Go – Phosphorylation, Alzheimer’s, dementia with Lewy bodies, ERK1/2, HMGB1, alpha synuclein, beta amyloid, glycyrrhizin
January 2019
Monthly Research Review – January 2019 – research overview, publications, clinical studies, new technology, reviews, videos
The Australian Parkinson’s Mission – multi-arm, clinical trial, repurposing drugs, genetics, biomarkers, substudies, disease modifying
An idea whose time has come – cell transplantation, embryonic stem cells, PARK2, PARKIN, PINK1, genetic variant, early onset, lewy bodies, Edinburgh, Dundee
Exciting Exenatide Exosomes – target engagement, blood, serum, plasma, AKT, MAPK, insulin, neuroprotection, clinical trial
Placebo. Nocebo. Gene-cebo? – genetics, DNA sequencing, variants, risk factors, direct-to-consumer, analysis, mutations, information
The “What would you do?” post – a post describing what I would do if I was diagnosed with Parkinson’s today.
The road ahead: Parkinson’s research in 2019 – expectations, clinical trials, 2019, therapeutics, drugs, treatments, cure, disease modifying therapies
December 2018
2018: Year in review – The annual review of Parkinson’s research for the year 2018
Monthly Research Review – December 2018 – research overview, publications, clinical studies, new technology, reviews, videos
From Alchemy to Alkahest – Alzheimer’s, blood, CCR3, chronokines, GDF11, GRF6019, GRF6021, Parabiosis, plasma, Stanford Parkinson’s Plasma Study,
The Parkinson’s Nebula? – Nebula Genomics, GWAS, genetic sequencing, risk factors, direct-to-consumer, 23andMe, PARK genes, genetics
EuPaTh: The Italian connection – European Parkinsons Therapy centre, Alex Reed, Italy, medical, physical, life style, psychological, 4 pillars, first steps
The lipidomics of Parkinson’s – Yumanity, stearoyl-CoA-desaturase, oleic acid, SCD, YTX-465, inhibitor, yeast, fatty acids, lipids, Mediterranean diet, monounsaturated fats
Denali: Phase Ib clinical trial starts – LRRK2, inhibitors, Leucine-rich repeat kinase 2, PARK8, G2019S, DNL-201, Sanofi, Centogene, clinical trial, RIPK1
The good, the GAD, and the not-so ugly – gene therapy, deep brain stimulation, Neurologix, subthalamic nucleus, Gamma-Aminobutyric acid, GABA, glutamic acid decarboxylase
Not bohemian, just ‘Rapsodi’ – GBA, Sanofi Genzyme, Ambroxol, glucocerebrosidase, Venglustat, PREDICT-PD, Fox insights, Gauchers disease
Thyme to look east: Baicalein – Baicalin, Baikal skullcap, traditional Chinese medicine, EGCG, alpha synuclein, aggregation, oligomers, fibrils
November 2018
Monthly Research Review – November 2018 – research overview, publications, clinical studies, new technology, reviews, videos
Brain. On. Fire. – NLRP3, inflammasome, inflazome, MCC950, inflammation, alpha synuclein, caspase 1, Nodthera, Jecure, IFM therapeutics, ibuprofen
York: #Parkinsons2018 – Parkinson’s UK, biennial research conference, Benevolent AI, United Neuroscience, inflammation, stem cell transplantation, exercise, Bluerock therapeutics
Mission: Not Impossible – Vibrohealth, wrist band, tremor antenuating devices, Microsoft, Emma Lawton, ALS, Eyewriter
Sensing seriousness about senolytics – senescent cells, senescence, SASP, SATB1, CDKN1A, Unity biotechnology, Oisin Biotechnologies, Dasatinib, Quercetin, Curcumin, Fisetin
We’re re-branding: It’s now called PARPinson’s – PAR, PARP, PARP1, poly ADP ribose polymerase, alpha synuclein, aggregation, Parthanatos, cell death
The potential benefits of missing an appendix – Appendicitis, alpha synuclein, association, appendectomy, oligomer, monomer, aggregation
October 2018
Monthly Research Review – October 2018 – research overview, publications, clinical studies, new technology, reviews, videos
Gene therapy: VY-AADC01 vs AXO-Lenti-PD – virus, clinical trial, update, AAV, lentivirus, AADC, OXB-102, Prosavin,
Targeting PDE1 for PD – phosphodiesterase, PDE1, inhibitor, clinical trial, Intra-Cellular Therapies, ITI-214, cAMP, cGMP
A Lewy body condition? – alpha synuclein, postmortem, LRRK2 p.R1441H, protein aggregation, LRRK2 inhibitors, PARK8, genetics
When you stop going native – tetramers, oligomers, alpha synuclein, mouse model, stablisation compounds
Monitoring Parkinson’s: Doctor, my glasses are listening to us – AudEERING, Emteq, facial expression, voice analysis, hypokinetic dysarthria, basal ganglia, wearable, technology
Grand times in Grand Rapids – Grand Challenges, Rallying, Linked Clinical trials, patient advocacy, prodromal, Van Andel Institute, Cure Parkinson’s Trust
The Bill and Melinda burden study – incidence of Parkinson’s, regional, national, global, Gates, foundation, disease burden, increase
September 2018
Monthly Research Review – September 2018 – research overview, publications, clinical studies, new technology, reviews, videos
Better call Sal(-butamol)? – Beta, Adrenoreceptor, agonists, antagonists, Propranolol, Salbutamol, asthma, hypertension, tremor, smoking
Administrative news: #Postac – Cure Parkinson’s Trust, new job, deputy director of research
Exercise: Taking the STING out of Parkinson’s – STING, inflammation, Nimbus Therapeutics, IFM therapeutics, PINK1, PARKIN, mitochondria
EGCG: Anyone fancy a cuppa? – Epigallocatechin Gallate, alpha synuclein, green tea, Promesa study, catechins, antioxidants, aggregation, oligomers
The ADHD study from Utah – ritalin, methylphenidate, retrospective study, PARKIN, PARK2, association, early-onset Parkinson’s
Aspirin: Barking up the right tree? – acetylsalicylic acid, cyclooxygenase, Salicylic acid, Spiraea, tyrosine hydroxylase, dopamine
The Kiwi Ketogenic study – clinical study, keto diet, low-fat diet, food, ketone bodies, New Zealand
August 2018
Monthly Research Review – August 2018 – research overview, publications, clinical studies, new technology, reviews, videos
EDITORIAL: BREXIT – a rant about the unforeseen consequences for scientific research of Britain’s decision to leave the European Union
Exenatide: Identifying the responders – clinical trial results, response, treatment, post hoc analysis, study, tremor-dominant, insulin resistant
On the hunt for biomarkers – biorepositories, specimens, biopies, tissue, DNA, RNA, samples, blood, serum, collection
DBS 3.0: Magnetise me? – magnetic field, glass catfish, electromagnetic perceptive gene, transcranial magnetic stimulation, deep brain stimulation
The Science of Constipation – gastrointestinal, discomfort, stool, feces, transit time, gut, laxatives, probiotics, clinical studies, trials, colon, small intestine, rectum
The genetics of Parkinson’s: New mutants – GWAS, genome wide association study, genetic variants, mutations, risk factors, PARK genes
ACT UP: Advocacy is Critical To Undoing Parkinson’s – patient advocacy, HIV, AIDS, direct action, protest
Back to back stimulation – spinal cord stimulation, deep brain stimulation, DBS, freezing of gait, Anticipatory postural adjustment, reactive postural response
Green light in Kyoto – induced pluripotent stem cells, IPS, dopamine neurons, cell replacement therapy, cell transplantation, clinical trial, Japan
July 2018
Monthly Research Review – July 2018 – research overview, publications, clinical studies, new technology, reviews, videos
Keep your sights on lymphocytes – T-cells, helper T-cells, IL-17, Interleukin 17, Regulatory T-cells, Secukinumab, Cosentyx, immune system
New LRRK2 results: Game changer? – LRRK2 inhibitors, Denali therapeutics, Leucine-rich repeat kinase 2, PINK1, DNL-201, DNL-151, LRRK1
Voyager Therapeutics update – clinical trial, gene therapy, AADC, VY-AADC, AAV virus, Phase II, FDA, Type C meeting, BLA
TRIMming aggregates – TRIM21, Huntington’s disease, Huntingtin, TAU, protein aggregation, Prothena, antibodies
Wanted: EEF2K inhibitors – oxidation, NRF2, redox, eukaryotic elongation factor-2 kinase, Longevica Pharmaceuticals, inhibitors, alpha synuclein
A tiny dot with an anti-Parkinson’s plot – graphene quantum dot, graphite, alpha synuclein, Alzheimer’s, beta amyloid, protein aggregation, fibrils, plaques
Lipid issues in ER = ZZZ issues in PD – PINK1, PARKIN, sleep, flies, mitochondria, endoplasmic reticulum, ER, Phosphatidylserine
The Big Hero 6 project – machine learning, artificial intelligence, spiral test, voice test, smart phone app, Intel, Project Paradigm
The Chinese stem cell trial – cell transplantation, clinical trial, embryonic stem cells, ISCO, Transeuro, parthenogenetic stem cells, Bluerock therapeutics, Novo Nordisk
June 2018
Monthly Research Review – June 2018 – research overview, publications, clinical studies, new technology, reviews, videos
Squalamine begets Trodusquemine – alpha synuclein, aggregation, dogfish shark, clinical trial, MSI-1436, ENT-01, RASMET, Enterin
Monitoring Parkinson’s: Putting your finger on it – key stroke, assessment, monitoring, MIT, Madrid, consortium, keyboard, touchscreen
Predicting subtypes of Parkinson’s – BioRxiv, Parkinson’s Progression Marker Initiative, PPMI, clusters, prognosis, Parkinson Disease Biomarker Program, PDBP
Prothena: Phase I results published – immunotherapy, antibodies, PRX002, clinical trial results, Phase I, alpha synuclein
Is Radotinib ABL to beat Nilotinib? – cancer drug, alpha synuclein, PARKIN, clinical trial, PD Nilotinib, NILO-PD, BRC-ABL inhibitor, Ilyang Pharmaceutical
Blessed are the suppressed – Immunosuppression, immunosuppressant drugs, corticosteroids, Inosine monophosphate dehydrogenase (IMDH) inhibitors, cortisone, hydrocortisone
What do you do with a problem like Exenatide? – NLY01, GLP-1 agonist, Neuraly, activated microglia, reactive astrocytes, mood, anxiety, clinical trial
Don’t get mad! Get NAD! – nicotinamide riboside, Nicotinic acid, Niacin, Nicotinamide, Nicotinamide adenine dinucleotide, GBA, Glucocerebrosidase
Xenon: A bright light for dyskinesias? – inhalation, noble gas, involuntary movements, Levodopa, L-dopa, neuroprotection
Keep an eye on mild TBI – traumatic brain injury, mild, moderate, severe, LRRK2
May 2018
Monthly Research Review – May 2018 – research overview, publications, clinical studies, new technology, reviews, videos
The Mannitol results – Clinicrowd, manna sugar, crowd sourced platform, olfaction, smell, osmolytes, molecular chaperones, HSP-70
To B3 or not to B3, that is the question – niacin, vitamin B3, clinical study, nicotinamide adenine dinucleotide, NAD+, GPR109A, macrophage, M1, M2, anti-inflammatory state
Two birds, one stone? – Tuberculosis, LRRK2, inhibitors, phagocytosis, phagosome, macrophage, PARKIN
Monitoring Parkinson’s: Let’s just sleep on it – IBM, Pfizer, Bluesky project, REM, NREM, clinical trial, Jazz Pharmaceuticals, Polysomnography, Solriamfetol
A vaccine for Parkinson’s – the AFFiRiS update – immunotherapy, antibodies, passive, active, immunity, Prothena, clinical trial, results
DUBstop: Oxford-style – deubiquitinating enzymes, DUB inhibitors, USP30, USP8, University of Oxford, FORMA Therapeutics, Ubiquitin Proteasome Pathway, autophagy, ubiquitin, Hybrigenics Pharma, Mission therapeutics
I’ll have the fish please – β-parvalbumin, calcium, alpha synuclein, protein aggregation, amyloid state, omega-3 fatty acids, docosahexaenoic acid
Planet Researcher to Planet Patient – a commentary/opinion piece regarding life in Parkinson’s research
When SERCA goes berserker – calcium, alpha synuclein, endoplasmic reticulum, ‘sarco/endoplasmic reticulum Ca2+-ATPase, thapsigargin, mipsagargin, G-202, Inspyr Therapeutics
On the importance of Calcium – alpha synuclein, synapse, vesicle, isradipine, action potential, neurotransmitter, STEADY-PD III, clinical trial
April 2018
Monthly Research Review – April 2018 – research overview, publications, clinical studies, new technology, reviews, videos
IBD+TNF AB ≠ PD? – inflammatory bowel disease, LRRK2, anti-TNF therapy, antibodies, inflammation, XPro1595
BIIB054: An immunotherapy update – antibody, Biogen, vaccine, clinical trial, phase I, Spark study, alpha synuclein, protein aggregation, oligomers, fibrils
Could heart failure medication be good for Parkinson’s? – Bumetanide, Bumex, loop diuretic, cholinergic, GABAergic, interneurons, striatum, NKCC1, chloride, antagonist, B&A Therapeutics
Diabetes and Parkinson’s – glucose intolerance, exenatide, bydureon, DPP-4 inhibitors, disease progression, association, epidemiological studies
Ibudilast: A Phosphodiesterase inhibitor – Amyotrophic Lateral Sclerosis, ALS, cAMP, cGMP, Multiple sclerosis, MR1916, dipyridamole, Vinpocetine, ITI-214, Intra-Cellular Therapies
UDCA 2.0 = TUDCA? – Ursodeoxycholic acid, Ursodiol, Tauroursodeoxycholic acid, bile acid, neuroprotection, clinical trial, repurposing drugs
The aggregating antics of (some) anaesthetics – Inhaled anesthetics, Phox2B, alpha synuclein, propofol, isoflurane, morphine, endoplasmic reticulum, ER stress, unfolded protein response
Is there NOP hope for Parkinson’s? – nociceptin/orphanin FQ, N/OFQ, nociceptin, receptor, ligand, dyskinesias, Blackthorn therapeutics, BTRX-246040, neuroprotection
March 2018
Monthly Research Review – March 2018 – research overview, publications, clinical studies, new technology
Objective measures: Getting smart about pills – Proteus, Medtronic, gastrointestinal tract, constipation, RASMET study, clinical trial, smart pills, digital pills
Making. It. Personal. – clinical trials, drugs, treatment, adaptive, I-SPY, MS-Smart, Stampede, EP-AD
Something is interesting in the state of Denmark – arimoclomol, orphazyme, biotech, ALS, clinical trial, GBA, Glucocerebrosidase, glucocerebroside, SOD1, molecular chaperones
“What’s the evolutionary advantage of Parkinson’s?” – LRRK2-G2019S, flies, vision, traits, contrast sensitivity, Edmond J. Safra lecture, King’s College London, occupation, jobs
The dilemma of success – a hypothetical problem that we may face in the not so distant future
Alpha Synuclein: New Species – AFFiRiS, Prothena, monomers, oligomers, fibrils, Pα-synF, Pα-syn*, antibodies, vaccine, autophagy, mitochondria
Happy birthday: Silverstein Foundation – Jonathan Silverstein, GBA, glucocerebrosidase, Prevail Therapeutics, Alector, resTORbio, REGENXBIO, gene therapy
Voyager Therapeutics: Phase I clinical trial update – VY-AADC, gene therapy, Oxford biomedica, dopamine, AAV virus, clinical trial
The Parkinson’s association-‘s’ – epidemiological study, 23andMe, Michael J Fox Foundation, PredictPD, migraines, obsessive-compulsive disorders, seasonal allergies, anemia, Honolulu Heart Study, liposuction, chin dimples
February 2018
Monthly Research Review – February 2018 – research overview, publications, clinical studies, new technology
An idea: “O Canada” – just an idea about better involving the Parkinson’s community in the research being conducted on PD
Reduce your RAGE as you AGE – glycation, sugar, lewy bodies, Azeliragon, vTv Therapeutics, Advanced Glycation Endproduct, receptor of Advanced Glycation Endproducts,
One black sheep per week – genetic variants, somatic mutations, hippocampus, prefrontal cortex,
Mickey becomes more human? – Atg7, autophagy, genetically engineered mice, mouse models, Lewy bodies, cellular inclusions
Spine-tingling research – spinal cord stimulation, pilot clinical study,
Trazodo or Trazodon’t? – Trazodone, antidepressant, repurposing drugs, neurodegenerative, dyskinesias,
The mystery of caffeine – coffee, metabolites, methylxanthine, adenosine 2A receptor, tea, theobromine
When the zombies are all in your head – cellular senescence, paraquat, herbicide, dopamine neurons, astrocytes, Unity biotechnology
January 2018
Monthly Research Review – January 2018 – research overview, publications, clinical studies, new technology
‘Talking bout my resolution’ – seeking feedback from readers regarding ideas for developing the SoPD website
Inspiration from a church in Mammoth – Jeremiah Pate, Daniela Zarnescu, alpha synuclein, chaperones, protein misfolding
EDITORIAL: That Pfizer news – opinion piece on Pfizer’s decision to terminate Alzheimer’s and Parkinson’s research
FASN-ating PINK research – Vitamin K2, PINK1, Parkin, FASN, TVB-2640, mitochondria, menaquinone, menatetrenone, MK-7, MK-4, Fatty acid synthase
When GCase is away, the GSLs will play – GBA1, Sanofi Genzyme, Ambroxol, Miglustat, Glycosphingolipids, Venglustat
The road ahead: Parkinson’s research in 2018 – expectations, clinical research, clinical trials, 2018, therapeutics, drugs, treatments
December 2017
2017 – Year in Review: A good vintage – annual review of Parkinson’s research
Multiple System Atrophy: A prion disease? – MSA-C, MSA-P, Parkinsonisms, oligomer, fibrils, alpha synuclein,
Novartis focuses on improving PARKIN control – CRISPR-Cas9, proteasome, mitophagy, PARK2, screening study, positive/negative regulators
Inhibiting LRRK2: The Denali Phase I results – Denali Therapeutics, DNL-151, DNL-201, LRRK2 inhibitors, clinical trial, phase I, Leucine-rich repeat kinase 2
James (Part 4): His legacy – James Parkinson, legacy, history, 200 years, anniversary, Arvid Carlson, William Rutherford Sanders, Charcot, Hornykiewicz, Gowers, Cotzias, Rowntree
A virtual reality for Parkinson’s: Keapstone – Parkinson’s UK, Nrf2, Keap1, biotech, drug development, oxidative stress
PAQ-ing more punch for Parkinson’s – Guadeloupe, French West Indies, Progressive supranuclear palsy, multiple system atrophy, PSP, MSA, Annonaceae, acetogenins, melatonin, Quinoxalines, PAQ, MPAQ, PPQ
The anti-depressing research of antidepressants – Depression, selective serotonin re-uptake inhibitors, tricyclic antidepressants, Amitriptyline, Nortriptyline
Non-invasive gene therapy: “You never monkey with the truth” – GBA, glucocerebrosidase, virus, alpha synuclein, Oxford Biomedica, Prosavin, Adeno-associated virus, AAV-PHP.B
Are Lewy bodies fake news? – cellular inclusions, aggregation, protein, alpha synuclein
November 2017
The EMPRSN talk #1 – public talk, video, Parkinson’s UK, clinical trials
The TAU of Parkinson’s – MAPT, microtubules, alpha synuclein, protein aggregation, genetic risk, haplotype, TRx0237, TauRx Pharmaceuticals,
Beware of the PINK-SNO(W) man! – PARKIN, PINK1, p53, mitochondria, mitophagy, Nitrosylation, S-nitrosylation reaction, environment
The Acorda’s Tozadenant Phase III clinical trials – adenosine A2a receptor antagonist, agranulocytosis, sepsis, Istradefylline,
Editorial: Orphan drug tax credit – rare disease, NORD, OOPD, ORD, Orphanet, EURORDIS, drug development, subsets, Parkinsonism,
James (Part 3): The man behind the disease – James Parkinson, 200 years, anniversary, history, London Correspondence Society, political radical, geology, paleontology
The LRRK Ascending – LRRK1, LRRK2, PARK8, Dardarin, G2019S,
CRISPR-Cas9: “New CRISPY Parkinson’s research” – gene editing, paraquat, POR, ATP7A, SLC45A4, yeast, alpha synuclein, DJ-1, PARK7, TNX, TIMM9, Editas Medicine,
October 2017
Clinical trials: The Power of One – I-SPY trial, Adaptive clinical trials, N-of-1 studies, caffeine, nicotine, simvastatin, Naftazone
“Three hellos” for Parkinson’s – Trehalose, glucose, autophagy, neuroprotection, inflammation, disaccharide, Junaxo, JNX3001, Bioblast Pharma
Are we getting NURR to the end of Parkinson’s disease? – Nurr1, NR4A2, SA00025, IRX4204, BRF110
Resveratrol’s neglected siblings – stilbenes, Pterostilbene, Piceatannol, NRF2, LRRK2, alph synuclein, stilbenoids
Trying to ‘beet’ Parkinson’s in the developing world – beetroot, red beet, developing world, L-dopa, Levodopa
PACAP and a snail model of Parkinson’s – Pituitary adenylate cyclase-activating polypeptide, G protein–coupled receptors, PAC1, VPAC1, VPAC2, Ac-[Phe(pI)(6), Nle(17)]PACAP(1-27)
A clever new Trk for Rasagiline – DOPAL, MAO-B inhibitors, Alpha Synuclein, BDNF, TrkB,
NIX-ing the PARKIN and PINK1 problem – mitochondria, mitophagy, Parkin, Pink1, Phorbol 12-myristate 13-acetate, NIX,
September 2017
We need a clinical trial of broccoli. Seriously! – Cruciferous vegetables, Brassicaceae, Cruciferae, Glucoraphanin, glucosinolate, Sulforaphane, NRF2, ARE, oxidative stress
Plan B: Itchy velvet beans – Mucuna pruriens – natural, L-dopa, levodopa, Ghana, fava beans
Food for thought! – fish oil, CAM Care, diet, nutritional supplement, iron, coenzymeQ10, PRO-PD, survey, online, soda, beef
AAV-PHP.B: The future is apparently now – non-invasive, gene therapy, Ambroxol, GBA, glucocerebrosidase, virus, alpha synuclein
O’mice an’ men – gang aft agley – Dopamine, oxidative stress, IPS cells, neuromelanin, alpha synuclein, glucocerebrosidase, N-acetylcysteine, NAC, Isradipine
QUATS going on?!? – triclosan, cetylpyridinium chloride, benzalkonium chloride, quaternary ammonium compounds, cetylpyridinium chloride, toothpaste
Voyager Therapeutics: phase Ib clinical trial results – VY-AADC01, AADC, gene therapy, AAV virus, Oxford Biomedica, Neurologix, Ceregene,
Beta2-Adrenoreceptor agonists: Another game changer? – Asthma, Clenbuterol, Salbutamol, Norway, Beta2-Adrenergic receptor,
August 2017
Dear FDA, this is bigly wrong…and you know it! – healthcare regulators, dopamine agonists, impulsivity, gambling, hypersexuality
Hey DJ, I-so-sit-rate! – DJ-1, Park7, Nrf2, oxidative stress, antioxidant, isocitrate dehydrogenase, isocitrate,
Mdivi-1: the small molecule that could? – mitochondria, division, fusion, P110, Kim Tieu, mitochondrial division inhibitor 1, neuroprotection
Self monitoring: there’s something in your eye – self tracking, Proteus, Google, Novartis, Alcon, Dexcom, smart lens, patch, pill
Lrrking in low orbit – ISS, International space station, microgravity, low-Earth orbit, Leucine-rich repeat kinase 2, inhibitors
Dementia with Lewy Bodies: New recommendations – Alzheimer’s disease, care, diagnosis, treatment, recommendations, Robin Williams,
DPP-4: Not a Star Wars character – Dipeptidyl peptidase-4, inhibitors, Sitagliptin, liraglutide, GLP-1, Granulocyte-macrophage colony-stimulating factor, Berberine, Lupeol
Exenatide: An editorial – phase II clinical trial, exendin-4, GLP-1 receptor agonist, Liraglutide, Lixisenatide, dilemma of success, size of effect
Exenatide: One step closer to joblessness! – phase II clinical trial, exendin-4, GLP-1 receptor agonist, gila monster, positive result!
The next killer APP: LRRK2 inhibitors? – Amyloid Precursor Protein, Alzheimer’s, Leucine-rich repeat kinase 2, Tau, Rab, G2019S, genetic mutation
July 2017
Nilotinib: the other phase II trial – abl inhibitor, clinical trial, gleevec, cancer drug, autophagy
The myth of Spring babies – seasonal, birth, schizophrenia, influenza, winter, spring, risk
The Agony and the Ecstasy – dyskinesias, Tim Lawrence, Horizon BBC, Ecstasy, MDMA, UWA-121, serotonin, subthalamic nucleus
Higher socioeconomic status jobs – Centre for Disease Control, CDC, Amyotrophic Lateral Sclerosis, socioeconomic, status, occupation, job, personality, traits
Helicobacter pylori: Unwanted passengers? – microbes, eradication, clinical study, gut, stomach,
DBS2.0: Look mum, no electrodes! – deep brain stimulation, non-invasive, electrodes, temporal interference stimulation, transcranial direct current stimulation,
Improving the SoPD blog 2017 – any thoughts/suggestions? – housekeeping, improvements, blog, website, suggestions, changes, ideas
The Llama-nation of Parkinson’s disease – antibodies, nanobodies, Ablynx, alpha synuclein, llamas
Future of gene therapy: hAAVing amazing new tools – virus, Oxford Biomedica, Prosavin, Caltech, Adeno-associated virus, AAV
Tetrabenazine: A strategy for Levodopa-induced dyskinesia? – tardive dyskinesia, Deutetrabenazine, Huntington’s disease, chorea,
A need for better regulation: Stem cell transplantation – embryonic stem cells, TP53, p53, genetic mutations, variants, cancer, stem cell clinics
Glutathione – Getting the k’NAC’k of Parkinson’s disease – acetylcysteine, NAC, antioxidant, EPI-589, Edison Pharmaceuticals,
The omnigenics of Parkinson’s disease? – genetics, alpha synuclein, height, GIANT, core genes, minor variants
June 2017
The other anniversary: 20 years of Alpha Synuclein – genetic mutation, 1997, Polymeropoulos, Nussbaum, Golbe, G209A, Salerno, Spillantini, Goedert
The autoimmunity of Parkinson’s disease? – alpha synuclein, T cells, autoimmune, MHC complex, autoantibodies, antigen, candesartan, Treg cells
On the hunt: Parkure – Flies, drosophila, cure, repurposed drugs, Scotland, Edinburgh, drug screening, NRF2, Astemizole, antihistamine, Ketoconazole
Cholesterol, statins, and Parkinson’s disease – lipoproteins, lipids, Hydrophilic, lipophilic, PD STAT, clinical trial, simvastatin,
Who am I but my BMI – weight, risk of Parkinson’s, body mass index,
BioRxiv – open access preprints – manuscripts, arxiv, lrrk2, alpha synuclein, publishing
Are Dyskinesias days NAM-bered? – Dipraglurant, mGluR5, negative allosteric modulator, Addex Therapeutics, Michael J Fox Foundation, dyskinesias
The Melanoma drug from MODAG – melanoma, skin cancer, alpha synuclein, Anle138b
Flu jabs and Parkinson’s disease – influenza, virus, vaccination, vaccine
New stem cell transplantation trial for Parkinson’s proposed in China – embryonic stem cells, clinical trial, China, neuronal-precursors
Oleuropein – “surely the richest gift of heaven?” – antioxidant, olive tree, phenylethanoid, hydroxytyrosol, mTOR, autophagy, Alzheimer’s disease
May 2017
James (Part 2): That essay – James Parkinson, history, essay on the shaking palsy, Paralysis agitans, 200 years, anniversary
Sheffield: flies, fish and a Tigar –
April 2017
Improving Patient Education – Introducing Eirwen Malin – Patient education, Winston Churchill Memorial Trust, fellowship, Eirwen Malin, USA, Argentina,
Wearable Tech 4 Parkinson’s – self tracking, smart phone apps,
Stress and Parkinson’s disease – cortisol, stress, hydrocortisone, adrenal gland,
Old dogs, new tricks – repurposing drugs for Parkinson’s – Dibenzoylmethane, Trazodone, Alzheimer’s, neurodegeneration, prion, repurposing drugs, eIF2alpha, PERK
Iron, life force, and Parkinson’s disease – Iron overload, Chelator therapy, Prana Biotechnology, PBT434, ADPD2017
On astrocytes and neurons – reprogramming for Parkinson’s – Yamanaka, IPS cells, induced pluripotent stem cells, Sweden,
An Ambroxol update – active in the brain – Ambroxol, GBA, glucocerebrosidase, lysosomes, clinical trial, update, genetic mutation
Stimulating research in London (Canada) – spinal cord stimulation, Miguel Nicolelis, Duke, Mandar Jog, Western University, clinical study
Editorial: Putting 200 years into context – 200 year anniversary, James Parkinson, research, science, context, alpha synuclein, GBA
Milestones in Parkinson’s disease research and discovery – 200 year anniversary, James Parkinson, research, science, clinical trials, discovery, Frank Church.
The Enlightened Mr Parkinson – author, interview, Cherry Lewis, James Parkinson, 200 year anniversary,
Hepatitis – Parkinson’s goes viral? – virus, hepatitis B, hepatitis C, Friedrich Heinrich Lewy, Lewy bodies, Negri bodies, rabies, post-encephalitic Parkinsonism, Taiwan, alpha synuclein,
James (Part 1): The man behind the disease – 200 year anniversary, James Parkinson,
March 2017
ADHD and Parkinson’s disease – Attention deficit hyperactivity disorder, dopamine, ritalin, methylphenidate, echogenicity, Park2, Parkin
Resveratrol: From the folks who brought you Nilotinib – red wine, antioxidants, sirtuins, grapes, Alzheimer’s, clinical trial, Parkin, Park2
A new theory of Parkinson’s disease – Ole Isacson, threshold, ascending, Simone Engelender, Braak, alpha synuclein, Lewy bodies, theory
A yeast model of Parkinson’s disease – Susan Lindquist, microorganism, yeast, genetics, RAB1, Nedd4, Yumanity
The Journal of Parkinson’s disease – special issue – 200 year anniversary, discoveries, special issue, OPEN ACCESS, L-dopa, history DBS, cell transplantation
The red headed mice of Boston – red hair, ginger, melanoma, MC1R, Nurr1, melanocortin-1 receptor
February 2017
Phase II trial launched for Nilotinib – cancer drug, Nilotinib, Georgetown University, clinical trial, phase II, Tasigna,
New kiwi research in Parkinson’s disease – Pericytes, tunneling nanotubes, alpha synuclein, lewy bodies, disease spread, New Zealand,
How pigs are helping with Parkinson’s disease – NTCELL, Living cell technologies, LCT, encapsulated cells, implantation, cerebrospinal fluid, choroid plexus, clinical trial,
Confirmation about that gut feeling? – microbiome, microbiota, gut, gastrointestinal tract, microorganisms, bacteria, sequencing
Pink flies in Leicester at it again – mitochondria, PINK1, PARKIN, flies, Leicester, ATF4
HIV and Parkinson’s disease – AIDS, HIV, virus, AIDS dementia complex, lentivirus, HAART
Busy day for Parkinson’s – 9/2/2017 – Blood test, diagnosis, neurofilament light chain, Nfl, Acorda therapeutics, inhalable L-dopa, clinical trial, phase 3
George H and Vascular Parkinsonism – mini stroke, George HW Bush, syndrome, Vascular, Arteriosclerotic, Parkinsonism, diabetes, high blood pressure, Macdonald Critchley,
On bans and boycotts – editorial, travel ban, Executive Order 13769, conferences, SfN,
PARIS is always a good idea – PARIS1, Pink1, Parkin, mitochondria,
Something ‘new and fresh’ from Korea – Kainos, Korea, Clinical trial, FAF1, KM-819, apoptosis, inhibitor
January 2017
Parkinson’s 101 (care of Parkinson’s UK) – what is Parkinson’s, clinical trial, drug design, videos, Michael J Fox, Parkinson’s UK
A smartphone application for Parkinson’s disease – umotif, monitoring, technology, clinical study,
An Update from Voyager Therapeutics trials for Parkinson’s – AADC, gene therapy, clinical trial, update,
The Dogfish solution for Parkinson’s – dogfish, Spurdogs, Mud shark, Squalide, Squalamine, alpha synuclein, MSI-1436
Niacin rich diets for Pink flies – Pink1, early onset Parkinson’s, Niacin, NAD+, mitochondria, nicotinamide, PARP,
An interesting commentary on the interpretation of the Nilotinib trial results – Nilotinib, clinical trial, MAO-B inhibitors, DOPAC, HVA
NRF2 and Parkinson’s disease – antioxidants, transcription factor, Antioxidant response elements, alpha synuclein, Lrrk2, Ayurveda, Curcumin, turmeric
Improving the SoPD blog – any thoughts? – house keeping post, requesting feedback
December 2016
The road ahead – Parkinson’s disease research in 2017 – clinical trials, key research areas, slowing the disease, basic biology, replacing lost cells, early detection
Update – Mannitol and Parkinson’s disease – Manna, sweetener, CliniCrowd, Israel, social impact,
Mmmm, Chocolate – xocolātl, cacao, β-phenylethylamine, Kuna indians, Panama, white chocolate, dark chocolate
Blood transfusions and Parkinson’s disease – Blood, transfusion, prion, Alzheimer’s
PREP-ing to treat Parkinson’s disease – prolyl oligopeptidase, PREP, serine protease, inhibitors,
A drug from Kalamazoo – Diabetes, Metabolic Solutions Development, MSDC-0160, Exenatide,
The biology of immortality and Parkinson’s disease – Shinya Yamanaka, IPS cells, regeneration, life extension
A brave new world: 21st Century Cures Act – Obama, FDA, new law, regulator, CDC
Gene therapy in Parkinson’s disease – virus, VY-AADC01, Voyager therapeutics, Aromatic L-amino acid decarboxylase, AADC, clinical trial,
Milk (Yes, milk) and Parkinson’s disease – milk, heptachlor epoxide, Honolulu Heart Study,
Gut reaction to Parkinson’s disease – microbiome, microglia, antibiotics, clinical study, Minocycline
November 2016
A new LAG in Parkinson’s – alpha synuclein, TM9SF2, Lag3, lymphocyte-activation gene 3, disease progression
Get more EGCG. Drink green tea – green tea, alpha synuclein, EGCG, Epigallocatechin Gallate, monomers, oligomers, fibrils, Lewy bodies
Update – ISCC Stem cell Transplantation trial – SFN, cell transplantation, clinical trial, Melbourne, Australia, International Stem Cell Corporation, ISCO, hpNSC
Something different – Government funding for Parkinson’s research – Trump, US elections, BREXIT, research funding, EU, science funding
Prothena reports Phase 1b results for Parkinson’s immunotherapy –
The benefits (???) of Antioxidants – clinical trial, Coenzyme Q, free radicals, orac, oxidation, vitamins
October 2016
Interesting reading – Nature, prion, lewy bodies, transplantation
Inhaling L-dopa – inhaler, Arvid Carlsson, Oleh Hornykiewicz, Levodopa, George Cotzias, Acorda Therapeutics,
PAMs for Parkinson’s – Prexton, PXT002331, globus pallidus, mGluR4 positive allosteric modulator, dyskinesias, clinical study
The curious case of Bulgarian Gypsies and the incidence of Parkinson’s disease – incidence, statistics, Amish, population, disease burden, Japan
September 2016
Cannabis and Parkinson’s disease – marijuana, medicinal use, clinical studies
The mystery deepens – Melanoma and Parkinson’s disease – skin cancer, genetics
First film footage of Parkinson’s disease – Arthur Van Gehuchten, cinematography, Youtube, Lancet
Update: Stem cells trial for Parkinson’s disease – cell transplantation, clinical trial, Melbourne, Australia, International Stem Cell Corporation, ISCO, hpNSC
Vaccine for Parkinson’s – AFFiRiS update – clinical trial, vaccination, alpha synuclein, antibodies, Austria
One year in – anniversary, happy birthday, 12 months
Game changer for Alzheimer’s – antibodies, clinical trial, Aducanumab, beta-amyloid, alpha synuclein, Biogen
August 2016
Is there something in my eye? – eyeball, retina, veins, arteries, diabetes, Rosiglitazone
Nilotinib update – new trial delayed – Nilotinib, cancer drug, delayed clinical trial
Coffee and Parkinson’s disease – it’s not just caffeine – coffee, caffeine, Quercetin, flavonoid
July 2016
Identical twins and Parkinson’s disease – Jeff and Jack Gernsheimer, GBA, Lrrk2, monozygotic, dizygotic, iPS cells, epigenetics
Pesticides and Parkinson’s disease – Farming, insecticides, rotenone, ground water, fungicides
Juvenile-onset Parkinson’s disease – PARK genes, Henri Huchard, Parkin, DJ1, Pink1, PODXL
Editorial note – Cambridge University, Stem cells, institute, Wellcome Trust, #MyView, awareness campaign
Traumatic brain injury and Parkinson’s disease – an association – traumatic brain injury, loss of consciousness, Alzheimer’s disease, Dementia pugilistica
Bees! Bees! Hark to your bees! – clinical trial, bee venom, Apitoxin, Apamin, Calcium channels
Nilotinib and Parkinson’s disease: an update – cancer drug, clinical trial, Tasigna, Novartis, leukemia, CML, autophagy, lysosome, c-Abl inhibitors
The GDNF Trial (Bristol) initial results – Glial cell-derived neurotrophic factor, GDNF, neurotrophic, MedGenesis, Bristol, Clinical trial, Parkinson’s UK, Cure PD Trust,
A gut feeling about gut feelings – vagotomy, Movement Disorder meeting, Berlin, Swedish, Danish, Norwegian
June 2016
New criteria for Parkinson’s disease – diagnosis, criteria, movement disorder
Your appendix and Parkinson’s disease – Appendectomy, alpha synuclein, gut, intestines, bacteria
Muhammad Ali (1942-2016) – famous, boxer, sports
May 2016
A change of dogma for Alzheimer’s disease? – beta amyloid, alpha synuclein, plaques, tangles, protein, aggregation, bacteria, microbes
The Autistic spectrum and Parkinson’s disease – Autism, aging, risk, incidence, PARK2, neuroleptics
Manna from heaven? Mannitol and Parkinson’s disease – alpha synuclein, sweetener, sugar, protein aggregation
The debate surrounding a new Stem cell transplantation trial for Parkinson’s – cell transplantation, clinical trial, Australia, International Stem Cell Corporation, ISCO, hpNSC
Finding PARK16 – PARK genes, genetics, ADORA1, familial
Blood test for Parkinson’s disease? – mitochondria, hyperactivity, clinical study, diagnosis
April 2016
An update on the connection between Melanoma and Parkinson’s disease – somatic mutations, PARK genes, Lrrk2, skin cancer
Helicobacter pylori and Parkinson’s disease – gut, intestines, microbes, bacteria, ALS-PDC, BMAA, Guam
Older siblings and Parkinson’s disease – brother, sister, Sweden, ALS, Schizophrenia
The Parkinson’s UK 2016 Gretschen Amphlet Memorial Lecture – Cambridge, Prof Barker, Parkinson’s UK, public lecture, cell transplantation, clinical trials
Something different – recognising a birthday – James Parkinson, anniversary, photo, portrait, Jean-Martin Charcot
Chromosome 22 and Parkinson’s disease – genetics, 22q11.2 deletion syndrome, DiGeorge syndrome, risk
March 2016
And now spit! – saliva, test, diagnosis, alpha synuclein
Another connection between skin and Parkinson’s disease – Rosacea, antibiotics, dermatitis
Does the age of onset make a difference? – statistics, demographics, early onset, juvenile Parkinsonism, Henri Huchard
Herpes Simplex virus and Alpha-Synuclein – immune system, antibodies, virus
Disco-needs-ya – the science of dyskinesias – involuntary movements, L-dopa, Chorea, Dystonia,
February 2016
A sense of (and the science of) smell – olfactory function, smell
Diagnosed 2500 years ago? No problem – India, Ayurveda, Kampa vata, Mucuna pruriens, L-dopa
Cleaning up with Ambroxol – Glucocerebrosidase, GBA, Ambroxol, clinical trial
Diabetes, Monster saliva, and Parkinson’s disease – glucose tolerance, diabetes, insulin, Gila monster, Exenatide, GLP-1 agonist, clinical trial
Something lrrk-ing in the water… – Lrrk2, Phosphorylation, urine, diagnostic test,
Brain (not Heart) warming research – warm brain, temperature
The science of focused ultrasound therapy – clinical trial, ultrasound, thalamotomy, pallidotomy
New Research – on how movement is controlled – basal ganglia, thalamus, direct/indirect pathways, optogenetics, dopamine
Improving diagnosis – autoantibodies, DATscan
New research – new targets of Lrrk2 – Lrrk2, Sergey Brin, dardarin, rab proteins
January 2016
New research – the disorder of Alpha Synuclein – monomeric, αlpha synuclein, protein aggregation
The vulnerability of dopamine cells in the brain – midbrain, dopamine, substantia nigra pars compacta, SNC, ventral tegmental area, VTA
New research – Urate and Parkinson’s – Ammonia, Inosine, antioxidant, blood
New Research -Shared genetic features – DNA methylation, common genetic markers, neurodegenerative disease
Viruses and Parkinson’s – a hit and run story? – influenza, H1N1, encephalitis lethargica, Spanish flu, H5N1, hepatitis C, chickenpox
The Placebo effect and Parkinson’s disease – dopamine, placebo, randomized double-blind study
Cell transplantation – Replacing what has been lost – Colorado, Columbia, Tampa Bay, clinical trials, Transeuro, Embryonic stem cells, lewy bodies
December 2015
GDNF and Parkinson’s disease – Synergen, glial cell-derived neurotrophic factor, neurturin, persephin, artemin, gene therapy, MedGenesis, NSgene, Amgen, Bristol, clinical trial
A call to arms – Parkinson’s, anniversary, 200 years
Parkinson’s disease and the cancer drug – Nilotinib, Tasigna, Novartis, leukemia, CML, autophagy, lysosome, clinical trial, c-Abl inhibitors
“Red hair, sir, in my opinion, is dangerous” – red hair, fair skin, frequency, incidence, MC1R
November 2015
The difference between men and women – frequency, incidence, Japanese, testosterone, Cox2
The Honolulu Heart Study – Japanese, smoking
October 2015
The smell of Parkinson’s disease – Joy Milne, Perth, Scotland, sebum, skin, odor, olfaction
September 2015
Do you have trouble lying? Parkinson’s and Personality traits – metabolism, prefrontal cortex
Vaccination for Parkinson’s disease – vaccine, alpha synuclein, AFFiRiS, clinical trial, vaccine, alpha synuclein, Prothena, Lewy body
Alzheimer’s news – prion, amyloid beta,
Melanoma and Parkinson’s – skin cancer
A gut feeling – intestines, stomach, vagus nerve, vagotomy
The Science of Parkinson's 