Tagged: clinical study

Exercise: Taking the STING out of Parkinson’s

 

In December of of 2017, the results of a clinical trial suggested that a particular  kind of exercise may have beneficial effects against certain aspects of Parkinson’s. Specifically, a high-intensity treadmill regime was found to be ‘non-futile’ as an intervention for the motor symptoms in de novo (newly diagnosed) Parkinson’s.

Recently, however, new pre-clinical research has been published which reported that when mice with particular Parkinson’s-associated genetic mutations are exercised to exhaustion, they have high levels of inflammation which can exaggerate the neurodegeneration associated with that model of PD.

So naturally, some readers are now asking “So should I be exercising or not?!?”

In today’s post we will review the results of the two studies mentioned above, and discuss why exercise is still important for people with Parkinson’s.

 


Readers are recommended to click on the image above and listen to the music (Michael Sembello’s “Maniac” from 1983) whilst reading this post.

This song was made famous by one particular scene from the 1983 movie “Flashdance” starring Jennifer Beals, in which the lead character undertook an intense dance routine. Ever since that iconic scene, exercise fanatics have long used the music to help get themselves into the mood for their workouts.

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One of my personal life goals. Source: Jobcrusher

Few experts would disagree that the benefits of exercise are many.

Adults who achieve at least 2.5 hours of physical activity per week have:

  • up to a 35% lower risk of coronary heart disease and stroke
  • up to a 50% lower risk of type 2 diabetes
  • up to a 50% lower risk of colon cancer
  • up to a 20% lower risk of breast cancer
  • a 30% lower risk of early death
  • up to an 83% lower risk of osteoarthritis
  • up to a 68% lower risk of hip fracture
  • a 30% lower risk of falls (among older adults)
  • up to a 30% lower risk of depression
  • up to a 30% lower risk of dementia

(Source: NHS)

But what about people with PD? What do we know about exercise and Parkinson’s?

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Monthly Research Review – March 2018

At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during March 2018.

The post is divided into four parts based on the type of research (Basic biology, disease mechanism, clinical research, and other news). 


So, what happened during March 2018?

In world news:

March 25th – Qantas launches direct non-stop Boeing 787 Dreamliner flights between Perth Airport and Heathrow Airport, making it the first commercially non-stop service between Australia and the United Kingdom (17 hours on a plane – strewth!).

Boeing 787 Dreamliner. Source: Deredactie

March 14th – Prof Stephen Hawking, English theoretical physicist and cosmologist, sadly passed away at age 76. Diagnosed with in a very rare early-onset, slow-progressing form of Amyotrophic lateral sclerosis (ALS; also known as motor neurone disease or MND) in 1963 at age 21, he was gradually left him wheel chair bound. An amazing mind and a sad loss.

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Prof Stephen Hawking. Source: BBC

A funeral for Prof Hawking was held in Cambridge. The bell at Great St. Mary’s tolled 76 times at the start of the service. His remains will be cremated and his ashes will be interred at London’s Westminster Abbey near the remains of Isaac Newton.

King’s Parade in Cambridge was absolutely packed with mourners. Source: News.rthk

March 19th – In other sad news, ‘Sudan’, the world’s last male northern white rhinoceros died in Kenya, making the subspecies ‘functionally extinct’. Poachers had reduced the population from 2000 in the 1960s to just 15 1980s, and efforts to keep the species alive .

Sudan, the last surviving male northern white rhino. Source: PBS

March 24 – In over 800 cities internationally, people participated in student-led demonstrations against gun violence and mass shootings, calling for stronger gun control in the ‘March for our lives‘.

Source: Marchforourlives

And finally, on the 17th March, a driver in Milton Keynes (UK) got into big trouble with the law when he was pulled over and presented a police officer with an obvious fake drivers license (Source: Sky News):

Fake news Mr Trump? Clearly a fake. Everyone knows Homer lives at 742 Evergreen Terrace!

In the world of Parkinson’s research, a great deal of new research and news was reported:

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