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This week some encouraging clinical trial results were announced by a biotech firm called Anavex Life Sciences.
The company had been testing their lead experimental therapy – a Sigma-1 receptor agonist called ANAVEX2-73 (also known as blarcamesine) – in 132 people with Parkinson’s disease dementia over a 14 week period.
The results are rather encouraging: significantly positive outcomes in both cognitive and motor symptoms.
In today’s post, we will explain what exactly “Sigma-1 receptor agonist” means, discuss what Parkinson’s disease dementia is, and review what we currently know about the results of the trial.
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A lot of clinical trials for disease modification in Parkinson’s are focused on targeting well known proteins that are believed to be associated with underlying biology of the condition, such as alpha synuclein, LRRK2, and GBA. We discuss these on a regular basis here on the SoPD.
There are, however, a large number of trials investigating less well known targets.
And this week we received news that one of these clinical trials had some positive results.
The study was conducted by the biotech company Anavex Life Sciences and it involved their lead experimental therapy ANAVEX2-73 (also known as blarcamesine).
ANAVEX2-73 is a Sigma-1 receptor agonist.
What does that mean?