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RNA – the usable copy of a section of DNA – has regions called introns that need to be removed before the RNA can be used for the production of protein. The process of removing introns is called splicing.
Recently researchers have noticed that a genetic mutation in a Parkinson’s-associated gene – called DJ-1 – affects the splicing of the associated RNA and this has serious consequences on the activity of the DJ-1 protein.
Interestingly, they were able to pharmacologically rescue the effect, and noticed that DJ-1 might not be the only Parkinson’s-associated gene affected by this splicing error.
In today’s post, we will discuss what splicing is, review the new research, and discuss the wider implications for the Parkinson’s community.
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Today’s post starts off with a definition:
Splice – /splʌɪs/; verb;
Meaning: “to combine, interweave”.
Origin: 16th century: probably from Middle Dutchsplissen,
Similar: braid, plait, entwine, intertwine, interlace, knit
1. (From the arts) When two pieces of recorded music – with a similar key and tempo – are combined:
2. (From biology) The process that removes the intervening, non-coding sequences of genes (introns) from pre-mRNA and joins the protein-coding sequences (exons) together in order to enable translation of mRNA into a protein:
Ok, so the first alternative definition about music I understood and the video was helpful, but can you explain the second definition in more detail please?