The “What would I do” post? Part 2

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I am very regularly asked “what would you do if you were diagnosed with Parkinson’s tomorrow?”

As a research scientist I don’t really feel comfortable answering it, but I can see how it is a fair question. I have previously attempted to address it (Click here to read that post), and I point folks who do ask in the direction of that post.

But a recent experience has me wanting to re-address it.

In today’s post, we will revisit this idea of what would I do if I were diagnosed with Parkinson’s tomorrow?

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Source: Newatlas

I lost someone extremely close to me early last year.

Even more than COVID19 or anything else that occurred, that singular event defined 2021 for me personally. There was life before, and now life adjusting to being without them.

And I’m not sharing this out of any desire for sympathy – honestly, I don’t want it. Everyone has suffered hardships over the last 2 years. Rather, I am telling you this for a very different reason.

It helps to set the context for the discussion today.

Continue reading “The “What would I do” post? Part 2″

Brain. On. Fire.

 

Inflammation is part of the immune system’s response to damage or infection. It is a very natural process that our bodies undergo when we come into harms way.

Researchers at the University of Queensland, have recently demonstrated something interesting about the inflammation associated with Parkinson’s: by inhibiting a very specific part of the inflammatory process, they can reduce the spread of Parkinson’s associated alpha synuclein pathology in models of PD.

And they have developed a drug – called MCC950 – that specifically targets that component of the inflammation process which they are now seeking to test in clinical trials.

In today’s post, we will discuss what inflammation is, review this new research, and consider what it could all mean for the Parkinson’s community.

 


Spot the unhealthy cell – exhibiting signs of stress (yellow). Source: Gettyimages

No silly preamble today – this is going to be a very long post, so we’re diving straight in:

When cells in your body are stressed or sick, they begin to release messenger proteins which inform the rest of your body that something is wrong.

When enough cells release these messenger proteins, it can cause inflammation.

What is inflammation?

Inflammation is a vital part of the immune system’s response to trouble. It is the body’s way of communicating to the immune system that something is wrong and activating it so that it can help deal with the situation.

By releasing the messenger proteins, injured/sick cells kick off a process that results in multiple types of immune cells entering the troubled area of the body and undertaking very specific tasks.

The inflammatory process. Source: Trainingcor

The strength of the immune response depends on the volume of the signal arising from those released messenger proteins.

And the level of messenger proteins being released partly depends on multi-protein structures called inflammasomes.

What are inflammasomes?

Continue reading “Brain. On. Fire.”

We need a clinical trial of broccoli. Seriously!

In a recent post, I discussed research looking at foods that can influence the progression of Parkinson’s (see that post here). I am regularly asked about the topic of food and will endeavour to highlight more research along this line in future post.

In accordance with that statement, today we are going to discuss Cruciferous vegetables, and why we need a clinical trial of broccoli.

I’m not kidding.

There is growing research that a key component of broccoli and other cruciferous vegetables – called Glucoraphanin – could have beneficial effects on Parkinson’s disease. In today’s post, we will discuss what Glucoraphanin is, look at the research that has been conducted and consider why a clinical trial of broccoli would be a good thing for Parkinson’s disease.


 

Cruciferous vegetables. Source: Diagnosisdiet

Like most kids, when I was young I hated broccoli.

Man, I hated it. With such a passion!

Usually they were boiled or steamed to the point at which they have little or no nutritional value, and they largely became mush upon contact with my fork.

The stuff of my childhood nightmares. Source: Modernpaleo

As I have matured (my wife might debate that statement), my opinion has changed and I have come to appreciate broccoli. Our relationship has definitely improved.

In fact, I have developed a deep appreciation for all cruciferous vegetables.

And yeah, I know what you are going to ask:

What are cruciferous vegetables?

Cruciferous vegetables are vegetables of the Brassicaceae family (also called Cruciferae). They are a family of flowering plants commonly known as the mustards, the crucifers, or simply the cabbage family. They include cauliflower, cabbage, garden cress, bok choy, broccoli, brussels sprouts and similar green leaf vegetables.

Cruciferous vegetables. Source: Thetherapyshare

So what have Cruciferous vegetables got to do with Parkinson’s?

Well, it’s not the vegetables as such that are important. Rather, it is a particular chemical that this family of plants share – called Glucoraphanin – that is key.

What is Glucoraphanin?

Continue reading “We need a clinical trial of broccoli. Seriously!”