# # # # Many researchers argue that there is no such thing as “Parkinson’s” (a singular disease that has a specific causal event and similar outcome). They also suggest that holding on to this idea is hurting our ability to develop better therapies to treat the condition. In today’s post, we will explore this idea further and look at a recent review article addressing it. # # # #

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Source: Azquotes

Nosology is the branch of medical science that deals with the classification of diseases.

The goal of nosology is to have “a description whose primary purpose is enabling a diagnostic label to be put on the situation” (Source).

Note here the use of the word ‘situation‘, instead of ‘disease‘ in the sentence above. Much of what doctors and clinicians face in medicine are not specific diseases. Rather, they are situations (or conditions) that need to be treated.

Think of stroke. It “is a medical condition in which poor blood flow to the brain causes cell death” (Source). Certain diseases (for example, diabetes or heart disease) may result in an individual having a stroke, but the stroke itself is typically a very individual condition/situation. And this is what clinicians attempt to treat.

We often think of diseases as being defined by a specific cause. Like the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection that leads to COVID-19. But even here the situation that doctors face can vary widely – some infected people die, while others are completely asymptomatic carriers of the virus.

Where are you going with this? You don’t think Parkinson’s is a ‘disease’?

Continue reading “Parkinsonism type 1 through infinity” →

# # # # For a very long time, curcumin has been used as a nutritional and medicinal agent by many cultures. Very recently, a clinical trial was conducted to explore the potential of curcumin on Parkinson’s. And the findings were interesting. In today’s post, we will review the review the results of that study (and others). # # # #

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Source: News-medical

Next time you are speaking with your neighbour, you should point out to them that there is a great deal of diversity in the number of species of Curcuma plants.

In India alone, there is approximately 40 to 45 species. And in Thailand there is another 30 to 40 species. Throughout tropical Asia there are numerous wild species of Curcuma, and even New Guinea and northern Australia are known to have Curcuma plants.

Curcuma plants. Source: Pacificbulbsociety

Curcuma is a perennial, herbaceous flowering plant that belongs to the broader ginger family. The plants can reach a height of one meter and they produce numerous, edible rhizomes (creeping rootstalk).

Rhizomes. Source: Etsy

The interior of these rhizomes are yellow or orange and can be reduced into a powder.

That powder is the spice we call turmeric.

Great. But what does turmeric have to do with Parkinson’s?

Continue reading “Spice up your life” →

# # # # I was reluctant to write this post given the media storm that tainted this drug during the early days of the COVID pandemic, but the science here is intriguing. Recently, researchers conducted a nationwide case-controlled study of 22,189 Finnish people diagnosed with Parkinson’s between 1996 to 2015. When they analysed their large dataset, they found an association between hydroxychloroquine and a lower risk of developing Parkinson’s. In today’s post, we will review this new research and discuss what could explain this curious finding. # # # #

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Dr Didier Raoult. Source: Letelegramme

On March 16, 2020, a video discussing a small study investigating the use of a drug called hydroxychloroquine in patients with SARS-CoV-2 was posted on YouTube (and a few days later a report on the study was made available).

It was an open-label, non-randomized study involving just 36 hospitalized patients with documented SARS-CoV-2 infections. It was a methodologically flawed study and making the results public without any kind of peer-review step was unethical, but this did not stop these results causing a media storm. And news of a potential first weapon in the fight against the new viral pandemic quickly spread, causing shortages in supplies of the drug for individuals with inflammatory conditions who actually needed it.

Eventually, a number of much larger and better designed clinical trials demonstrated that the drug did not represent a sensible treatment against COVID (Click here to read more about this).

But sadly, a previously very useful treatment became somewhat tainted. And it has since been the subject of many jokes, cartoons and memes:

Source: TheWeek

Despite its 15 minutes of ignominy though, hydroxychloroquine is still a very useful drug and it may still hold one or two surprises.

Great. But what does this have to do with Parkinson’s? 

Continue reading “Hydroxychloroquine… I kid you not” →

# # # # According to collected statistics, about 85% of the world’s people identify with a religion (Source).  Curiously, new research suggests that people in the remaining “non-religious” 15% may be at higher risk of developing Parkinson’s. In today’s post, we will review the new research and try to understand this strange association. # # # #

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Source: Gotquestions

Before we start, I think that it is only fair to state that while I fully respect the rights of others to believe and practice what they want in terms of philosophical/religious beliefs (as long as it does not harm), I am an apatheist.

Pray tell, what is an apatheist? Is that like an atheist?

No.

The apatheist position holds that the existence or non-existence of God(s) is utterly irrelevant. We are apathetic towards the question of “God”.

It is not a stance based on skepticism (like atheists or agnostics), but rather a lack of interest in the subject matter itself. Basically, the big picture question does not warrant any time or effort in the life of an apatheist. We simply do not care.

(I say “we”, but I am not a card-carrying member of any formal group, it is simply the designation that I can define myself by when folks come knocking on my door)

And for the record, my daughter is a practicing Christian, and I support her in her faith.

Ok, very nice, thanks for sharing, but…uh,… what does this have to do with Parkinson’s?

Actually, new research suggests quite a lot.

What do you mean?

Continue reading “Finding religion” →

# # # # At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during June 2022. The post is divided into 10 parts based on the type of research: Top 7 pieces of Parkinson’s news Articles of general interest Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Conferences/lectures Other news Review articles/videos # # # #

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So, what happened during June 2022?

In world news:

June 9th – researchers reported that Zophoba Morio “superworms” were perfectly happy to eat plastic. The worms could partially digest foamed polystyrene (Styrofoam) and gain weight, suggesting they were able to attain some nutrition from the material (Source).

 

June 13th – A senior software engineer at Google named Blake Lemoine was suspended after sharing transcripts of a conversation with an artificial intelligence known as  LaMDA (Language Model for Dialogue Applications) that Lemoine claimed to be “sentient”.

 

June 14 – Canada and Denmark ended their competing claims for Hans Island. The island lies in the middle of the Kennedy Channel between Greenland and Ellesmere Island. By dividing the island roughly in half, the two countries peacefully ended the 40+ years “Whisky War“.

 

June 24th  – The US Supreme Court overruled Roe in Dobbs v. Jackson Women’s Health Organization on the grounds that the substantive right to abortion was not “deeply rooted in this Nation’s history or tradition“, nor considered a right when the Due Process Clause was ratified in 1868, and was unknown in U.S. law until Roe (Source).

 

June 29th – Scientists (at the International Earth Rotation and Reference Systems Service – an organization in charge of global timekeeping) recorded the shortest day on Earth since the invention of the atomic clock. Our planet’s rotation measured in at 1.59 milliseconds short of the normal 24-hour day (Source).

In the world of Parkinson’s research, a great deal of new research and news was reported:

In June 2022, there were 864 research articles added to the Pubmed website with the tag word “Parkinson’s” attached (6,209 for all of 2022 so far). In addition, there was a wave to news reports regarding various other bits of Parkinson’s research activity (clinical trials, etc).

The top 7 pieces of Parkinson’s news

Continue reading “Monthly Research Review – June 2022” →